What is inositol Monophosphatase?

What is inositol Monophosphatase?

Inositol phosphate-phosphatase, commonly referred to as IMPase, are enzymes of the phosphodiesterase family of enzymes.

Does lithium reduce inositol?

Lithium may deplete inositol by inhibiting IMPase and by decreasing the transport of myo-inositol into cells (Lubrich and van Calker, 1999).

What are the effects of lithium on the enzyme inositol Monophosphatase?

IP is finally broken down into myo-inositol by the enzyme inositol monophosphatase (IMPase). Lithium inhibits IMPase, leading to myo-inositol depletion. Myo-inositol is also the substrate for synthesis of phosphatidylinositol (PI), which is phosphorylated to form mono-, bis- and tris- phosphatidylinositol.

What does Myo-Inositol do?

Myo-inositol (MI) increases insulin sensitivity, decreases hyperandrogenism and improves the menstrual cycle. Its effect during assisted reproductive technologies (ART) has been studied by many authors.

What is the inositol depletion theory?

Inositol depletion hypothesis – valproic acid & lithium exert their therapeutic effects by depleting inositol. Bipolar disorder (BD) patients exhibit altered levels of inositol in brain. Inositol depletion is a common outcome of structurally disparate antibipolar drugs.

What does Myo Inositol do?

What is the function of inositol?

Inositol might balance certain chemicals in the body to help with mental conditions such as panic disorder, depression, and obsessive-compulsive disorder. It might also help insulin work better. People use inositol for metabolic syndrome, polycystic ovary syndrome (PCOS), and for reducing the risk of preterm birth.

Does lithium inhibit inositol monophosphate?

Lithium chloride (LiCl) inhibits inositol monophosphatase (IMPase) at therapeutic concentrations.

Does inositol cross the blood brain barrier?

We found that inositol promotes the traversal of Cryptococcus across the blood-brain barrier (BBB), and such stimulation is fungal inositol transporter dependent. We also identified the effects of host inositol on fungal cellular functions that contribute to the stimulation of fungal penetration of the BBB.

What is the mechanism of action of lithium?

Lithium acutely stimulates the NMDA receptor, increasing glutamate availability in the postsynaptic neuron. After chronic administration, lithium induces NMDA downregulation, this way lithium modulates glutamate neurotransmission. In the previous slides we saw how lithium inhibits excitatory neurotransmission.

How does inositol provide energy?

Inositol supports your body’s healthy insulin processing mechanisms. Insulin is a hormone made by the pancreas and released into the bloodstream. Insulin allows our cells to take in glucose (sugar) and produce energy.

What is inositol in biochemistry?

Inositol, or more precisely myo-inositol, is a carbocyclic sugar that is abundant in the brain and other mammalian tissues; it mediates cell signal transduction in response to a variety of hormones, neurotransmitters, and growth factors and participates in osmoregulation.

How does myo-inositol work?

How does inositol work in the brain?

Inositol affects the processes that make neurotransmitters, the molecules responsible for relaying information within your brain ( 1 ). Serotonin is one important neurotransmitter affected by inositol. This molecule has many roles in your body and impacts your behavior and mood (2).

Does lithium reduce glutamate?

At a neuronal level, lithium reduces excitatory (dopamine and glutamate) but increases inhibitory (GABA) neurotransmission; however, these broad effects are underpinned by complex neurotransmitter systems that strive to achieve homeostasis by way of compensatory changes.

Does lithium block D2 receptors?

[3H] Spiperone binding to the striatal membranes increased in the rats treated with lithium, while the Western blotting analysis showed no change of the amount of the dopamine D2 receptors. These results suggested that lithium might induce the conformational changes of the dopamine D2 receptors.

What is the purpose of inositol?

Inositol plays a structural role in your body as a major component of cell membranes ( 2 ). It also influences the action of insulin, a hormone essential for blood sugar control. In addition, it affects chemical messengers in your brain, such as serotonin and dopamine ( 3 , 4 ).

What is the nature of inositol?

The inositols are the nine isomeric forms of cyclohexanehexol, a group of small and chemically very stable polar molecules that have versatile properties.