What are kallikrein inhibitors?
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What are kallikrein inhibitors?
Kallikrein inhibitors are a class of drugs used to prevent and treat attacks due to an inherited immune disease “hereditary angioedema” (HAE) in adults and children aged 12 years and older.
What deficiency causes hereditary angioedema?
The symptoms of hereditary angioedema type I develop due to a deficiency of a protein known as complement component C1 esterase inhibitor. Hereditary angioedema type II is a more uncommon form of the disorder and may occur because of abnormal C1 esterase proteins that do not function properly.
Is there a cure for hereditary angioedema?
Hereditary angioedema cannot be cured, but medicines can help prevent and treat the swelling.
How do you manage hereditary angioedema?
Treatment of Hereditary Angioedema: Replacement therapy or immune modulating medicines pertaining to hereditary angioedema. Intravenous medication to treat acute attacks of hereditary angioedema. To prevent angioedema due to C1 esterase inhibitor deficiency.
How do you get rid of HAE?
The FDA approves the following drugs for the treatment of HAE.
- Berinert (C1 esterase inhibitor, human)
- Cinryze (C1 esterase inhibitor intravenous, human)
- Haegarda (C1 esterase inhibitor subcutaneous, human)
- Firazyr (Icatibant)
- Kalbitor (Ecallantide)
- Orladeyo (Berotralstat)
- Ruconest (C1 esterase inhibitor, recombinant)
Where is kallikrein found in the body?
the pancreas
In 1934, Eugen Werle reported finding a substance in the pancreas of humans and various animals in such large amounts that the pancreas could be taken for its site of origin. He named it kallikrein, by derivation from the Greek word for pancreas.
Does prednisone help angioedema?
For severe hives or angioedema, doctors may prescribe a short course of an oral corticosteroid drug — such as prednisone — to reduce swelling, inflammation and itching.
How do you reduce swelling from angioedema?
For cases of allergic and idiopathic angioedema, antihistamines and oral steroids (steroid tablets) can be used to relieve the swelling. Drug-induced angioedema can usually be treated by using an alternative medication to treat whatever underlying condition you have.
How long does hereditary angioedema last?
On average, untreated individuals have an attack every 1 to 2 weeks, and most episodes last for about 3 to 4 days. The frequency and duration of attacks vary greatly among people with hereditary angioedema, even among people in the same family.
