How is diabetic dyslipidemia treated?
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How is diabetic dyslipidemia treated?
Nonpharmacologic interventions (diet and exercise) are first-line therapies and are used with pharmacologic therapy when necessary. Lowering LDL levels is the first priority in treating diabetic dyslipidemia. Statins are the first drug choice, followed by resins or ezetimibe, then fenofibrate or niacin.
What is first-line treatment for dyslipidemia?
HMG-CoA reductase inhibitors, or statins, are the recommended first-line therapy for most patients. These are the most prescribed drugs in the world and are considered the most effective lipid-lowering agents available, both in lowering LDL-C levels and in the prevention of CV events.
What is the relationship between diabetes and dyslipidemia?
Diabetic dyslipidemia is characterized by elevated fasting and postprandial triglycerides, low HDL-cholesterol, elevated LDL-cholesterol and the predominance of small dense LDL particles. These lipid changes represent the major link between diabetes and the increased cardiovascular risk of diabetic patients.
Which statin is best for diabetics?
Rosuvastatin administered at moderate and high doses, and Simvastatin and Atorvastatin administered at high doses were the most effective treatments in patients with diabetes by using non-HDL-C as a primary measure.
What meds are used for diabetes who have high cholesterol?
Pravastatin (Pravachol) and lovastatin (Altoprev) are two lower-potency options. If you need to combat high cholesterol more aggressively, your doctor may prescribe rosuvastatin (Crestor), which is the most powerful statin, or atorvastatin (Lipitor) at higher doses.
Which drug indicated for dyslipidemia?
The most commonly used options for the pharmacologic treatment of dyslipidemia are statins, resins, fibrate, niacin, and their combinations.
What is the primary treatment for hyperlipidemia?
Statins are the mainstay of treatment for hyperlipidemia, including use in FH. Seven statins are currently approved by the FDA for the treatment of hyperlipidemia in combination with a heart-healthy diet.
Why does type 2 diabetes cause dyslipidemia?
Insulin resistance is central to the pathogenesis of type 2 diabetes and contributes to dyslipidemia [17]. Insulin resistance is associated with increased levels of serum insulin and depletion of β-cells and results in impaired regulation of circulating lipoprotein and glucose levels [7, 13].
Why is type 2 diabetes a risk factor for dyslipidemia?
Dyslipidemia is one of the major modifiable risk factors for cardiovascular diseases (CVD) in a type-2 diabetic (T2DM) patient. Dyslipidemia in T2DM patients is attributed due to increased free fatty acid flux secondary to insulin resistance.
Should a diabetic take statins?
Currently, the American Heart Association, American College of Cardiology, and the American Diabetes Association recommend that all adults ages 40 to 75 who have type 2 diabetes should take a statin to prevent cardiovascular disease related to atherosclerosis.
Why is statin therapy recommended for diabetics?
In contrast to statin treatment that is not based on any LDL levels or target treatment thresholds, hypertension treatment is still based on blood pressure levels, and blood pressure control is encouraged for individuals with diabetes….Expert Analysis.
| Risk factor | Age | Statin intensity |
|---|---|---|
| No risk factor | >75 | Moderate or high |
How does metformin reduce hyperlipidemia?
Metformin Lowered LDL-C Levels by Regulating the PCSK9-LDLR Axis In Vivo. Metformin improves glucose and triglyceride metabolism and regulates cholesterol metabolism in both diabetic and nondiabetic individuals. Two hyperlipidemia mouse models were employed to investigate the effect of metformin on LDL-C homeostasis.
Should diabetics take cholesterol meds?
The ADA recommends a moderate statin dose for people with diabetes who are under 40, or 40 to 75 without any other risks for heart disease. A high statin dose is recommended for people with diabetes who have heart disease, and for those between 40 and 75 who have other risk factors for heart disease.
What is the best treatment for hyperlipidemia?
The basis of treating hyperlipidemia remains diet, physical exercise and weight reduction. Olive oil and nuts have been shown to be beneficial. Statins remain first line drug treatment. Further treatment options are ezetimibe, bile acid sequestrants, fibrates and fish oil.
How does diabetes cause hyperlipidemia?
The non-insulin-dependent diabetic (NIDDM) patient with mild fasting hyperglycemia commonly has mild hypertriglyceridemia due to overproduction of TG-rich lipoproteins in the liver, associated with decreased high-density lipoprotein (HDL) cholesterol levels.
Should all diabetics be on a statin?
High-dose statin therapy is recommended for all patients with diabetes with a history of clinical atherosclerotic CVD or with at least one additional CVD risk factor. Moderate-dose statin therapy is also suggested for patients younger than 40 or older than 70 who have CVD risk factors.
