Which diuretic is used for nephrogenic diabetes insipidus?

Which diuretic is used for nephrogenic diabetes insipidus?

Nephrogenic diabetes insipidus. Treatment with the drug hydrochlorothiazide (Microzide) may improve your symptoms. Although hydrochlorothiazide is a type of drug that usually increases urine output (diuretic), it can reduce urine output for some people with nephrogenic diabetes insipidus.

How is hydrochlorothiazide used to treat nephrogenic diabetes insipidus though it is diuretic agent?

Hydrochlorothiazide is a thiazide diuretic that decreases urinary volume in the absence of ADH. It may induce mild volume depletion and cause proximal salt and water retention, thereby reducing flow to the ADH-sensitive distal nephron.

Is hydrochlorothiazide used to treat diabetes insipidus?

Lithium is the most common cause of nephrogenic diabetes insipidus (Li-NDI). Hydrochlorothiazide (HCTZ) combined with amiloride is the mainstay treatment in Li-NDI.

Why do you give thiazide diuretics for diabetes insipidus?

If you have more severe nephrogenic diabetes insipidus, you may be prescribed a combination of thiazide diuretics and a non-steroidal anti-inflammatory drug (NSAID) to help reduce the amount of urine your kidneys produce.

What is the mechanism of action of hydrochlorothiazide?

Mechanism of Action Hydrochlorothiazide inhibits sodium chloride transport in the distal convoluted tubule. More sodium is then excreted in the kidney with accompanying fluid. Pharmacological effects begin in about 2 hours after an oral dose, peak in 4 hours, and lasts for about 6 to 12 hours.

Can lithium be taken with hydrochlorothiazide?

hydrochlorothiazide oral increases toxicity of lithium carbonate oral by reducing drug removal from the body. Monitor CloselyUse Caution/Monitor.

How does hydrochlorothiazide work in diabetes insipidus?

Abstract. Thiazides have been used in patients with nephrogenic diabetes insipidus (NDI) to decrease urine volume, but the mechanism by which it produces the paradoxic antidiuretic effect remains unclear.

Why should lithium not be taken with hydrochlorothiazide?

What might happen: Your blood levels of lithium may increase and cause toxic effects such as nausea, vomiting, diarrhea, drowsiness, loss of appetite, muscle weakness, slurred speech, trembling, blurred vision, confusion, seizures, dizziness, or increased urination.

Are thiazides contraindicated in diabetes?

Prolonged thiazide diuretic therapy can lead to glucose intolerance and may occasionally precipitate diabetes mellitus. Short-term metabolic studies, epidemiologic studies, and a variety of clinical trials suggest a connection between ongoing thiazide diuretic use and the development of type 2 diabetes.

Is hydrochlorothiazide contraindicated in diabetes?

While thiazide diuretics are still a recommended medication of hypertension therapy for type 2 diabetes, treatment with low-dose HCTZ should be attempted to evaluate the effectiveness and adverse metabolic effects.

Why do doctors prescribe hydrochlorothiazide?

Hydrochlorothiazide is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.

What medication should not be taken with hydrochlorothiazide?

Lithium. In general, lithium shouldn’t be taken with hydrochlorothiazide. That’s because hydrochlorothiazide slows the clearance of lithium from your body. This increases your risk of high levels of lithium in your body, which can cause dangerous side effects.

Can you give lithium with hydrochlorothiazide?

Can you take hydrochlorothiazide with diabetes?

hydroCHLOROthiazide metFORMIN HydroCHLOROthiazide can increase blood sugar levels and interfere with diabetic control. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications.

How do thiazide diuretics treat nephrogenic DI?

Thiazide diuretics inhibit the NaCl co-transporter (NCC/TSC) in the renal distal convoluted tubule (DCT) (8). The DCT is water impermeable and considered to be part of the diluting segment (8). Therefore, the water-preserving effect of thiazides is unlikely related to a direct effect on the DCT.