What is the drug of choice in hyperemesis gravidarum?

What is the drug of choice in hyperemesis gravidarum?

Ondansetron (Zofran), while pregnancy Class B, has become the most common parenteral and oral antiemetic used in US emergency departments due to its efficacy, and it has become the first choice in hyperemesis in the last several years—especially since it became available in a generic form.

Is there any treatment for hyperemesis gravidarum?

Treatment methods include a range of options, including maternal diet and lifestyle alterations, administration of intravenous fluids, antiemetics or steroids, and alternative therapies such as acupuncture and hypnosis.

How will you manage a case of hyperemesis gravidarum?

Small frequent meals: Nausea and vomiting might be treated with dry foods (such as crackers) and small, frequent meals. Intravenous fluids: It is important for a pregnant woman to maintain her fluid intake. Intravenous (IV) fluids might be needed if a woman continues to vomit throughout pregnancy.

What is the best antiemetic in pregnancy?

Pharmacologic Therapy for Nausea and Vomiting of Pregnancy

Medication	Dosage*
Antiemetics
	Chlorpromazine (Thorazine)	10 to 25 mg orally two to four times daily
	Prochlorperazine (Compazine)	5 to 10 mg orally three or four times daily
	Promethazine (Phenergan)	12.5 to 25 mg orally every four to six hours

What is the best anti nausea medication for pregnancy?

Meclizine (Antivert), diphenhydramine (Benadryl), and dimenhydrinate (Dramamine) all help relieve pregnancy-related nausea. A review of over 35 studies found these antihistamines to be safe. And, studies have found that they’re better than placebo at treating nausea in pregnancy.

What antiemetics are safe during pregnancy?

Antiemetics used in pregnancy include; metoclopramide, prochlorperazine cyclizine, promethazine and ondansetron. These medicines are listed in Table 1 in a suggested order in which to try them, however, individual patient factors and adverse effect profiles may alter this.

What is the best medicine for vomiting in pregnancy?

Medications for Morning Sickness (Vomiting During Pregnancy)

• ondansetron (Zofran)
• promethazine (Phenergan)
• prochlorperazine (Compazine)
• metoclopramide (Reglan)
• trimethobenzamide (Tigan)
• doxylamine succinate and pyridoxine hydrochloride (Diclegis, anti-nausea newly approved version of an older nausea drug)

Which antiemetic is safe in pregnancy?

Which antiemetics are safe in pregnancy?

Why is ondansetron given for hyperemesis gravidarum?

Ondansetron is a very effective medicine that works by blocking the action of chemicals in the body that trigger nausea and vomiting. Ondansetron can greatly improve quality of life in women with hyperemesis gravidarum, as well as helping to prevent the serious complications that can be caused by this condition.

Can I take metoclopramide while pregnant?

Importance Metoclopramide, a drug frequently used for nausea and vomiting in pregnancy, is thought to be safe, but information on the risk of specific malformations and fetal death is lacking.

What are common antiemetics used to treat both outpatient and inpatient hyperemesis gravidarum?

Nausea and vomiting of pregnancy and hyperemesis gravidarum are common off-label uses of ondansetron. In a small randomized trial, use of ondansetron resulted in clinically significant reductions in both nausea and vomiting compared with the combination of doxylamine and pyridoxine [79].

Which medicine is best for nausea and vomiting in pregnancy?

Diphenhydramine is commonly used in pregnancy for treatment of nausea and vomiting as well as allergy symptoms (rhinitis, pruritus) and insomnia; available safety data are generally reassuring that it is not a teratogen [58-60].

Is Stemetil safe in early pregnancy?

Like most phenothiazine medicines, Stemetil is not recommended for use during pregnancy. If there is a need Page 2 STEMETIL® 2 to take Stemetil during your pregnancy, your doctor will discuss with you the benefits and risks of using it. Tell your doctor or pharmacist if you are breastfeeding or plan to breastfeed.

Is cyclizine prescription only UK?

About cyclizine It is available from a pharmacy, without a prescription, and can be taken by adults and by children over the age of 6 years.

Is ondansetron safe in pregnancy NHS?

Ondansetron used after around week 10 of pregnancy would not be able to cause these problems as the baby is fully developed by this stage. There are no concerns that ondansetron use in pregnancy affects the chance of miscarriage, stillbirth, preterm delivery or low infant birth weight.

Can a GP prescribe ondansetron?

Ondansetron is classified BLUE for this indication – it can be prescribed in primary care by general practitioners, with the recommendation that only one pack is prescribed (1 x 10 tablets).

What is the safest antiemetic in pregnancy?

Antiemetic drugs safe for pregnancy Motion sickness drugs like meclizine and dimenhydrinate are safe for pregnant women. Vitamin B-6 and dopamine antagonists have been found to be safe, but are only used in severe cases of morning sickness.