What are the methods of dry granulation?

What are the methods of dry granulation?

Methods of dry granulation

• Slugging technique.
• Roller compaction.
• Weighing formulation ingredients.
• Mixing of formulation ingredients.
• Compression of mixed powders into slugs.
• Milling and sieving of slugs.
• Mixing with disintegrant and lubricant.
• Compression of granules into tablets.

What is RMG principle?

Working principle of RMG: Rapid mixture granulator works on agitation, tumbling. The impeller is responsible for uniformly mixing wet granules, and the chopper helps in a break or reduced particle size. At the starting process or during binder addition, the impeller and chopper generally operate at low speed.

What is the principle of granulation?

Granulation is a process in which powder particles are made to adhere to each other, resulting in larger, multi-particle entities, so called granules. If such a process is performed without adding liquids, this is called dry granulation.

What is granulation principle?

What is granulation fluid made of?

The granulation liquid (fluid) contains a solvent or carrier material which must be volatile so that it can be removed by drying, and depending on the intended application, be non-toxic. Typical liquids include water, ethanol and isopropanol either alone or in combination.

What is SLUG in granulation?

Slugging is a pre-compression process for the formation of extra large tablets (slugs), usually of variable weight, due to poor flow of the drug powder. The resulting slugs are subsequently broken down into granules, which are recompressed to obtain the final tablets.

Should I slug every night?

For best results, Dr. Que recommends using the slug life routine at night to ensure that your skin is as clean as possible before putting on your moisturizer. And Dr. Sisto says you can do it as frequently as every night if you wish.

Can I use niacinamide before slugging?

Additionally, Marchbein doesn’t advise applying petroleum jelly over ingredients like retinol or hydroxy acids, as it can increase penetration and lead to irritation. “If you are going to slug, just use the jelly over mild ingredients like ceramides, hyaluronic acid, or niacinamide,” she suggests.

What is amperage in RMG?

What Is Ampere Load In RMG? Ampere load is the current which is used by the chopper and impeller for the rotation of powder or granules. Ampere load is high at the start of the process and then gradually decreases as the load on the motor decreases.

Which colours are granulating?

This type is usually given the name “French Ultramarine” and is used when a strong granulation effect is required. Other typical examples of granulating colours are Cobalt Blue & Cobalt Green, Cerulean Blue, Raw Sienna, Green Earth, Gold Ochre and Oxide Black.