How does benzene affect the bone marrow?

How does benzene affect the bone marrow?

Excessive exposure to benzene has been known for more than a century to damage the bone marrow resulting in decreases in the numbers of circulating blood cells, and ultimately, aplastic anemia.

Does benzene bioaccumulate?

Environmental Fate: Benzene can volatilize into the air from water and soil (2, 76). Benzene can break down within a few days in air, whereas benzene breaks down more slowly in water and soil. It can also easily leach from the soil into groundwater. Benzene does not bioaccumulate in plants or animals.

Does benzene cause multiple myeloma?

IARC classifies benzene as “carcinogenic to humans,” based on sufficient evidence that benzene causes acute myeloid leukemia (AML). IARC also notes that benzene exposure has been linked with acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin lymphoma.

How Does benzene cause acute myeloid leukemia?

Benzene has been shown to cause chromosome changes in bone marrow cells in the lab. (The bone marrow is where new blood cells are made.) Such changes are commonly found in human leukemia cells.

How do you make cumene?

Cumene (isopropyl benzene) is produced by reacting propylene and benzene over an acid catalyst. Cumene may be used to increase the octane in gasoline, but its primary use is as a feedstock for manufacturing phenol and acetone.

What is benzene poisoning?

Benzene poisoning occurs when someone swallows, breathes in, or touches benzene. It is a member of a class of compounds known as hydrocarbons. Human exposure to hydrocarbons is a common problem. This article is for information only. DO NOT use it to treat or manage an actual poison exposure.

What cancers Does benzene cause?

The Department of Health and Human Services (DHHS) has determined that benzene causes cancer in humans. Long-term exposure to high levels of benzene in the air can cause leukemia, cancer of the blood-forming organs.

Can benzene cause CML?

“Known to be a human carcinogen” – National Toxicology Program (NTP) A 2012 study found that benzene exposure can increase the risk of chronic myeloid leukemia (CML) by 23 percent.

Do Cigarettes contain benzene?

Benzene in tobacco smoke For smokers, tobacco smoke is the most important source of exposure to benzene. It is released in the smoke when tobacco is burned. Non-smokers are also exposed through tobacco smoke when they inhale smoke passively.

Is there benzene in Coca Cola?

Benzene is listed as a known carcinogen, although the FDA assured it did not present an immediate health risk at the levels found to date in drinks. Coca-Cola said it had tested drinks for benzene in the past, and stated “unequivocally that our products are safe”​.

Does Pepsi have benzene?

“Pepsi Twist has been falsely promoted as a safe consumer product, when in fact, it contains the ingredients ascorbic acid and potassium benzoate, which can and do produce the carcinogenic chemical benzene when exposed to heat and light,”​ the lawsuit, filed by lawyers Howard Hewell and Howard Rubinstein, alleges.

Where is cumene used?

Cumene, also known as isopropylbenzene, 2-phenylpropane or (1-methylethyl) benzene, is widely used as a chemical intermediate in the production of phenol and acetone. Cumene is also used as a thinner for paints, lacquers, and enamels and it is a natural component of coal tar and petroleum.

What chemical causes leukemia?

Who benzene drinking water?

EPA has set 5 ppb as the maximum permissible level of benzene in drinking water . EPA has set a goal of 0 ppb for benzene in drinking water and in water such as rivers and lakes because benzene can cause leukemia . EPA estimates that 10 ppb benzene in drinking water that is consumed regularly or exposure to 0 .