Which drugs are examples of alkylating agents used in chemotherapy?

Which drugs are examples of alkylating agents used in chemotherapy?

Examples of alkylating agents include:

• Altretamine.
• Bendamustine.
• Busulfan.
• Carboplatin.
• Carmustine.
• Chlorambucil.
• Cisplatin.
• Cyclophosphamide.

How do antitumor antibiotics work?

Antitumor antibiotics are cell cycle nonspecific. They act by binding with DNA and preventing RNA (ribonucleic acid) synthesis, a key step in the creation of proteins, which are necessary for cell survival. They are not the same as antibiotics used to treat bacterial infections.

Which are antitumor antibiotics?

The antitumor antibiotics consist of dactinomycin, adriamycin, bleomycin, mithramycin, and mitomycin-C. They function as cell-cycle-nonspecific DNA intercalating agents, interfering with DNA and RNA synthesis [8,21].

What are the antitumor drug?

anticancer drug, also called antineoplastic drug, any drug that is effective in the treatment of malignant, or cancerous, disease. There are several major classes of anticancer drugs; these include alkylating agents, antimetabolites, natural products, and hormones.

Is an example of alkylating agent?

Some examples of alkylating agents are nitrogen mustards (chlorambucil and cyclophosphamide), cisplatin, nitrosoureas (carmustine, lomustine, and semustine), alkylsulfonates (busulfan), ethyleneimines (thiotepa), and triazines (dacarbazine).

Which of the following is not an example of alkylating agent?

Note: Although the platinum-containing anticancer agents, carboplatin, cisplatin, and oxaliplatin are frequently classified as alkylating agents, they are not.

What is vinblastine made of?

Vinblastine is a chemical analogue of vincristine, an alkaloid derived from the Madagascar periwinkle plant Vinca rosea (Catharanthus roseus), from which it derives its name.

What are examples of cytotoxic drugs?

Some examples of cytotoxic antibiotics include:

• anthracyclines such as: doxorubicin (Lipodox) valrubicin (Valstar)
• non-anthracyclines such as: bleomycin (Blenoxane) dactinomycin (Cosmegen)

What are antimetabolites with example?

Antimetabolites. Antimetabolites are group of anticancer agents that exert their cytotoxic effects by interfering with the DNA synthesis. Some of the important drugs from this class are 5-fluorouracil (5-FU), capecitabine, floxuridine, cytarabine, gemcitabine, decitabine, and vidaza.

Is lovastatin competitive inhibitor?

Abstract. Lovastatin is a potent competitive inhibitor of the rate-limiting enzyme of cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (NADPH) [HMG-CoA reductase; (S)-mevalonate:NADP+ oxidoreductase (CoA-acylating), EC 1.1. 1.34].

Is methotrexate a JAK inhibitor?

Methotrexate Is a JAK/STAT Pathway Inhibitor.

What is the name of vinca alkaloids and its uses?

They have been used to treat diabetes, high blood pressure and have been used as disinfectants and anti-cancer. The vinca alkaloids have cytotoxic effects that can arrest the division of cells and causes cell death. There are four major vinca alkaloids in clinical use: VBL, VRL, VCR and VDS.