What is Tcga pan cancer?

What is Tcga pan cancer?

Program Description. The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels.

Why is Tcga important?

The TCGA researchers have so far collected a broad range of genomic data of individual cancer types, yielding a better understanding of the biology and pathology of each tumour, and resulting in the development of specific treatment strategies.

Where does TCGA data come from?

TCGA used a compendium of standard operating procedures for processing tissues and other biological samples into molecular analytes for molecular characterization. These protocols are available from NCI’s Biospecimen Research Database.

What does TCGA stand for?

The Cancer Genome Atlas (TCGA), a landmark cancer genomics program, molecularly characterized over 20,000 primary cancer and matched normal samples spanning 33 cancer types.

What is TCGA analysis?

TCGA Computational Tools The Cancer Genome Atlas (TCGA) catalyzed considerable growth and advancement in the computational biology field by supporting the development of high-throughput genomic characterization technologies, generating a massive quantity of data, and fielding teams of researchers to analyze the data.

How big is TCGA?

TCGA data are currently over 1.2 Petabyte in size and include whole genome sequence (WGS), whole exome sequence (WXS), methylation, RNA expression, proteomic, and clinical datasets.

Does TCGA have normal tissue?

Xena offers two sources of normal tissue: TCGA’s solid tisue normal samples from individuals with cancer, and GTEX normal tissue from individuals who do not have cancer.

Do pheochromocytomas metastasize?

Pheochromocytomas are tumors arising from chromaffin tissue located in the adrenal medulla associated with typical symptoms and signs which may occasionally develop metastases, which are defined as the presence of tumor cells at sites where these cells are not found.

What is the data in TCGA?

TCGA data is available in two tiers: Open Access: Public data not unique to an individual and not requiring user certification. These data include deidentified clinical and demographic data, gene expression, copy number alterations, epigenetic data, compiled summaries, and anonymized single amplicon DNA sequence data.

Does TCGA have treatment data?

The Cancer Genome Atlas (TCGA) represents a valuable source of genomic and clinical data across different tumor types. In this work, TCGA treatment response information have been manually curated in order to be computationally exploited.

Can pheochromocytoma go away?

Pheochromocytoma is rare, and it is not usually cancerous. However, without treatment, it can lead to serious complications. Removing the tumor will usually cause the symptoms to go away. However, a doctor may recommend lifelong follow up, as some pheochromocytomas can recur.