What is Netupitant palonosetron used for?
Table of Contents
What is Netupitant palonosetron used for?
Netupitant and palonosetron combination is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy). Palonosetron and netupitant work by blocking the signals to the brain that cause nausea and vomiting.
What is the drug classification for palonosetron?
Palonosetron is in a class of medications called 5-HT3 receptor antagonists. It works by blocking serotonin, a natural substance in the body that causes nausea and vomiting.
Is palonosetron better than ondansetron?
In adult patients receiving moderately emetogenic chemotherapy, palonosetron has been shown to be superior as a single agent to ondansetron or dolasetron at preventing both acute and delayed chemotherapy-induced nausea and vomiting.
Is palonosetron a chemo drug?
Palonosetron is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderate to highly emetogenic cancer chemotherapy….Table 2.
| 5-HT3 receptor antagonist | Intravenous dose (mg) | Cost/day |
|---|---|---|
| Granisetron (Kytril)† | 1 | $195.20 |
| Palonosetron (Aloxi) | 0.25 | $372.00‡ |
What are the side effects of palonosetron?
Side Effects
- Blurred vision.
- chest pain or discomfort.
- difficult breathing.
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly.
- irregular heartbeats that continue.
How often can you give palonosetron?
Palonosetron is a long acting medication that has a duration of action of 3 to 5 days. In most instances, only one dose needs to be given to prevent nausea and vomiting from chemotherapy. However, in some cases where chemotherapy is given for more than three days in a row, a second dose of palonosetron may be given.
How long does Aloxi last?
Palonosetron is a long acting medication that has a duration of action of 3 to 5 days. In most instances, only one dose needs to be given to prevent nausea and vomiting from chemotherapy.
How much does palonosetron cost?
The cost for palonosetron intravenous solution (0.25 mg/5 mL) is around $16 for a supply of 5 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Does palonosetron cause constipation?
Purpose: Palonosetron, a long-acting 5-HT3 receptor antagonist, is an effective antiemetic agent for chemotherapy-induced nausea and vomiting; however, it sometimes causes severe constipation.
Is Aloxi and Zofran the same?
Ondansetron and palonosetron are anti-nausea medications used to prevent nausea and vomiting caused by cancer chemotherapy and to prevent vomiting and nausea after surgery. Brand names for ondansetron include Zofran, Zofran ODT, and Zuplenz. A brand name for palonosetron is Aloxi.
What is the best anti nausea medication for chemo?
However, if the chemotherapy is likely to cause nausea and vomiting, your doctor may prescribe one or more of the following common anti-nausea medications:
- Aprepitant (Emend®)
- Dolasetron (Anzemet®)
- Granisetron (Kytril®)
- Ondansetron (Zofran®)
- Palonosetron (Aloxi®)
- Proclorperazine (Compazine®)
