How does azithromycin Work?
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How does azithromycin Work?
Azithromycin belongs to the class of drugs known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. This medicine is available only with your doctor’s prescription.
What does TROVAN do?
Trovan is indicated for the treatment of patients initiating therapy in in-patient health care facilities (i.e., hospitals and long term nursing care facilities) with serious, life- or limb-threatening infections caused by susceptible strains of the designated microorganisms in the conditions listed below.
What is the mechanism of action of erythromycin?
Erythromycin acts by inhibition of protein synthesis by binding to the 23S ribosomal RNA molecule in the 50S subunit of ribosomes in susceptible bacterial organisms.
How does erythromycin inhibit bacterial growth?
Erythromycin inhibits bacterial protein synthesis by reversibly binding with their 50 S ribosomal subunit, thus blocking the formation of new peptide bonds. Erythromycin is classified as a bacteriostatic antibiotic.
What is the mechanism of action of macrolides?
The mechanism of action of macrolides revolves around their ability to bind the bacterial 50S ribosomal subunit causing the cessation of bacterial protein synthesis.
How is azithromycin metabolized?
Metabolism is predominantly hepatic (to inactive metabolites), with biliary excretion a major pathway of elimination. Drug elimination is biphasic, with a terminal half-life of up to 5 days.
Who made Trovan?
In the mid-1990s, Pfizer developed Trovafloxacin Mesylate, an antibiotic that is also known by its brand name as “Trovan”.
What is the difference between erythromycin and azithromycin?
Conclusions: Azithromycin stimulates antral activity similar to erythromycin and moreover has a longer duration of effect. However, unlike erythromycin, azithromycin does not have significant drug-drug interactions and maybe a potential new medication for the treatment of gastroparesis and gastrointestinal dysmotility.
Where is azithromycin metabolized?
Metabolism is predominantly hepatic (to inactive metabolites), with biliary excretion a major pathway of elimination.
What are the mechanism of antibacterial action and the antibacterial spectrum of macrolides?
Macrolides act as antibiotics by binding to bacterial 50S ribosomal subunit and interfering with protein synthesis.
Is azithromycin metabolized by cyp450?
Azithromycin and dirithromycin neither inhibit cytochrome P450 enzymes nor are implicated in clinically significant drug-drug interactions.
Does azithromycin inhibit CYP3A4?
Azithromycin has been shown to be a weak substrate for CYP3A4, to be minimally metabolized by the enzyme, and to neither induce nor inhibit CYP3A4 activity [16].
What are the dangers of azithromycin?
[3-12-2013] The U.S. Food and Drug Administration (FDA) is warning the public that azithromycin (Zithromax or Zmax) can cause abnormal changes in the electrical activity of the heart that may lead to a potentially fatal irregular heart rhythm.
Why was the Pfizer case unethical?
The suit charges that Pfizer did not obtain informed consent from the sick children’s parents and that a failure to adhere to the study protocol resulted in brain damage, hearing loss and the death of 11 of the 2,000 children in the study.
Is Nigeria suing Pfizer?
In a case that could create new liabilities for U.S. research conducted abroad, 30 Nigerian families have sued pharmaceutical giant Pfizer Inc., alleging that the company unethically tested an antibiotic on their children during a 1996 meningitis outbreak.
What is the pharmacokinetics of azithromycin?
The bioavailability of azithromycin is approximately 37%. Concomitant administration of oral azithromycin with food significantly decreases by 50% drug bioavailability. Following a single oral 500 mg dose, peak plasma concentrations of about 0.35-0.45 mg/l are attained within approximately 2 hours.
What is the mechanism of action of macrolide antibiotics?
