What is the action of AquaMEPHYTON?

What is the action of AquaMEPHYTON?

AquaMEPHYTON is indicated for prophylaxis and treatment of vitamin K-deficiency bleeding in neonates.

What is the mode of action for vitamin K?

Vitamin K is the blood-clotting vitamin. The mechanism of action of vitamin K is discussed in terms of a new carbanion model that mimics the proton abstraction from the gamma position of protein-bound glutamate. This is the essential step leading to carboxylation and activation of the blood-clotting proteins.

What is the expected pharmacological action of Phytonadione?

Phytonadione (vitamin K) is used to prevent bleeding in people with blood clotting problems or too little vitamin K in the body. Phytonadione is in a class of medications called vitamins. It works by providing vitamin K that is needed for blood to clot normally in the body.

Can AquaMEPHYTON be given to newborns?

The American Academy of Pediatrics recommends that vitamin K1 be given to the newborn. A single intramuscular dose of AquaMEPHYTON 0.5 to 1 mg within one hour of birth is recommended.

What is AquaMEPHYTON used for in newborns?

Phytonadione is indicated for prophylaxis and treatment of vitamin K-deficiency bleeding in neonates.

Is AquaMEPHYTON the same as vitamin K?

AquaMEPHYTON injection is a yellow, sterile, aqueous colloidal solution of vitamin K1, with a pH of 5.0 to 7.0, available for injection by the intravenous, intramuscular, and subcutaneous routes. AquaMEPHYTON is available in 1 mg (2 mg/mL) and 10 mg (10 mg/mL) single-dose ampuls.

What is the role and mechanism of vitamin K in blood clotting?

Vitamin K helps to make four of the 13 proteins needed for blood clotting, which stops wounds from continuously bleeding so they can heal. People who are prescribed anticoagulants (also called blood thinners) to prevent blood clots from forming in the heart, lung, or legs are often informed about vitamin K.

How does vitamin K work in the body?

Vitamin K refers to a group of fat-soluble vitamins that play a role in blood clotting, bone metabolism, and regulating blood calcium levels. The body needs vitamin K to produce prothrombin, a protein and clotting factor that is important in blood clotting and bone metabolism.

How does vitamin K work in blood clotting?

Can vitamin K stop bleeding in pregnancy?

Vitamin K helps your baby’s blood clot and prevents serious bleeding.

Does vitamin K shot cause jaundice?

Another myth is that the vitamin K injection increases the risk of jaundice—which is inaccurate. Jaundice associated with vitamin K has been observed only in high risk babies (such as premature babies) in doses 30-60 times higher than the dose we give.

Why vitamin K injection is given in pregnancy?

Vitamin K helps your baby’s blood to clot. Babies need more vitamin K than they get from their mother during pregnancy or from breast milk. Parents of all newborns are offered a vitamin K injection for their baby soon after birth. This helps prevent babies from becoming vitamin K deficient.

When do you give vitamin K to INR?

For an invasive procedure to be performed within 24 hours, 0.5 to 1 mg phytonadione IV may be given by slow infusion (60 minutes) for INR within the therapeutic range. May recheck INR 12 hours after phytonadione dose. If still elevated, consider administering FFP or an additional dose of 0.5 mg of phytonadione IV.

What clotting factors does vitamin K activate?

The clotting factors involved are FII, FVII, and FIX. These are all vitamin K-dependent and are usually associated with a variable bleeding tendency. For 2 of these factors, FII and FIX, the association with thrombosis, besides the clinical observation, has been demonstrated by molecular studies.

What clotting factors are vitamin K-dependent?

The vitamin K-dependent coagulation factors are factors II, VII, IX, X, proteins C and S. Combined deficiency of the vitamin K-dependent factors may result from missense mutations in the genes for vitamin K reductase (VKORC-1) or gamma-glutamyl carboxylase.

Can vitamin K lower BP?

Getting an adequate intake of vitamin K may also be essential to your heart health because it may be able to help prevent hypertension (abnormally high blood pressure) and lower your risk of cardiovascular disease (more on that in a second).

What is vitamin K-dependent clotting factors?

Prothrombin, FVII, FIX, protein C, and protein S are vitamin K-dependent clotting factors or proteins strictly related to blood coagulation. The ties of another protein, protein Z with blood coagulation, is less evident or still poorly defined.

What is the role of calcium ions and vitamin K in blood clotting?

The ability to bind calcium ions (Ca2+) is required for the activation of the several vitamin K-dependent clotting factors, or proteins, in the coagulation (clotting) cascade. The term, coagulation cascade, refers to a series of events, each dependent on the other, that stop bleeding through clot formation.

Which injection is given to stop bleeding in pregnancy?

Tranexamic acid has been proposed and used for prevention and management of antepartum and postpartum hemorrhage. Detailed Description: Bleeding during pregnancy is associated with a three- to fourfold increase in perinatal mortality.