What is IL-2 cancer treatment?

What is IL-2 cancer treatment?

Aldesleukin is an immunotherpay drug. It is also known as interleukin 2 (IL-2) or by its brand name Proleukin. It is a treatment for kidney cancer that has spread to another part of the body (advanced kidney cancer). It is also used in clinical trials for other types of cancer.

In what category of cancer treatments does the use of interleukin-2 belong?

Interleukin-2 (IL-2) is one of the key cytokines with pleiotropic effects on immune system. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma.

What is the name of the doctor that treated cancer patients with IL-2 immunotherapy?

Theodore Logan, M.D., associate professor of clinical medicine at the IU School of Medicine and a physician scientist at the IU Simon Cancer Center, is an immunotherapy expert. He specializes in interleukin-2, a type of cytokine.

What treatments work best for melanoma?

The main treatment for melanoma is surgical removal, or excision, of the primary melanoma on the skin. The extent of the surgery depends on the thickness of the melanoma. Most melanomas are found when they are less than 1.0 mm thick, and outpatient surgery is often the only treatment needed.

How is interleukin-2 administered?

Interleukin-2 is given in two different ways. It can be given in higher doses into a vein (IV, intravenously) while the patient is monitored in the hospital. It can also be given in a low-dose regimen via a shot placed under the skin (SubQ, subcutaneous injection).

Why is interleukin administration a promising therapy for cancer?

Interleukin-2. IL-2 is viewed as a key cytokine in promoting the expansion of natural killer (NK) cells and T lymphocytes. Thus, it is widely used in protocols of adoptive transfer for both expanding lymphocytes in culture and increasing the persistence of transferred cells in cancer patients.

What are the side effects of interleukin-2?

Side effects of IL-2 can include flu-like symptoms such as chills, fever, fatigue, and confusion. Some have nausea, vomiting, or diarrhea. Many people develop low blood pressure, which can be treated with other medicines.

Can immunotherapy cure metastatic cancer?

An experimental form of immunotherapy that uses an individual’s own tumor-fighting immune cells could potentially be used to treat people with metastatic breast cancer, according to results from an ongoing clinical trial led by researchers at the National Cancer Institute’s (NCI) Center for Cancer Research, part of the …

What is the new treatment for melanoma?

In a large clinical trial, people with advanced melanoma treated with nivolumab (Opdivo) and a new drug called relatlimab—which targets a protein called LAG-3—lived longer without their cancer getting worse than those treated only with nivolumab. Both nivolumab and relatlimab are immune checkpoint inhibitors.

Can melanoma be cured with immunotherapy?

Immunotherapy is the use of medicines to help a person’s own immune system recognize and destroy cancer cells more effectively. Several types of immunotherapy can be used to treat melanoma.

Is IL-2 proinflammatory or anti-inflammatory?

Both proinflammatory (IL2, IL6, IFNgamma, TNFalpha) and anti-inflammatory (IL4, IL10) cytokines were significantly increased in infected infants compared with non-infected infants.

What are the side effects of interleukin 2?