What is Cremophor in?
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What is Cremophor in?
Cremophor EL (CrEL) is a formulation vehicle used for various poorly-water soluble drugs, including the anticancer agent paclitaxel (Taxol). In contrast to earlier reports, CrEL is not an inert vehicle, but exerts a range of biological effects, some of which have important clinical implications.
What is Cremophor rh 40?
Cremophor RH 40® A non-ionic solubilizer and emulsifying agent that is obtained by reacting hydrogenated castor oil with ethylene oxide. Cremophor® RH 40 is used to solubilize ethereal oils, perfume compositions, vitamins and hydrophobic active substances in aqueous- alcoholic and purely aqueous solutions.
What drugs contain Cremophor?
Cremophor is a synthetic, nonionic surfactant made by reacting castor oil with ethylene oxide. It is widely used for water-insoluble drugs, including paclitaxel, cyclosporine, propofol, althesin, propanidid, and vitamin supplements.
Does paclitaxel contain polyethylene glycol?
Fatty acid esters of polyethyleneglycol are also present, as well as hydrophilic polyethylene glycols and ethoxylated glycerol. It is present in intravenous formulations of the anticancer drugs teniposide and paclitaxel. The paclitaxel formulation consists of 6 mg/ml in 50% ethanol and 50% Cremophor.
Is Cremophor a surfactant?
Cremophor EL, a non-ionic surfactant, promotes Ca(2+)-dependent process of cell death in rat thymocytes. Toxicology.
Is Cremophor EL toxic?
Cremophor EL is an excipient with toxic effects on humans such as vasodilation, labored breathing, leth- argy, hypersensitivity, cardio-toxicity, life-threatening anaphylaxis, aggregation of erythrocytes, nephrotoxicity, and neurotoxicity in many patients (Gelderblom et al., 2001).
What is PEG 40 hydrogenated castor oil?
PEG 40 hydrogenated castor oil is used in cosmetics as a solubiliser, emulsifier, surfactant and emollient. It is derived from Castor oil and is useful in producing products that disperse in water whilst offering good moisturising properties.
What is Polyoxyl hydrogenated castor oil?
Polyoxyl castor oil and polyoxyl hydrogenated castor oil are nonionic surfactants, which are used as emulsifying and solubilising agents in pharmaceutical preparations and cosmetics.
What are the ingredients in Taxol?
Taxol® (NSC 125973) Paclitaxel, the most well-known natural-source cancer drug in the United States, is derived from the bark of the Pacific yew tree (Taxus brevifolia) and is used in the treatment of breast, lung, and ovarian cancer, as well as Kaposi’s sarcoma.
What is paclitaxel made of?
Paclitaxel, the most well-known natural-source cancer drug in the United States, is derived from the bark of the Pacific yew tree (Taxus brevifolia) and is used in the treatment of breast, lung, and ovarian cancer, as well as Kaposi’s sarcoma.
What are the ingredients in paclitaxel?
Each vial contains Paclitaxel, PEG-35 castor oil, anhydrous citric acid and absolute ethanol. Paclitaxel is a natural product with antitumour activity. It is a white to off white crystalline powder that is highly lipophilic and insoluble in water.
What is polysorbate used for?
Polysorbates are widely used to protect biological drug products from protein unfolding, aggregation, and precipitation during both shipping and handling. The polysorbates are amphipathic, nonionic surfactants made of fatty acid esters of polyoxyethylene sorbitan.
What is polyoxyl 35 castor oil?
What is the difference between Taxol and Abraxane?
Abraxane is a different form of paclitaxel than Taxol. Both medicines are taxanes, a powerful type of chemotherapy that can stop cancer cells from repairing themselves and making new cells. Taxol uses a solvent called Cremophor EL to dissolve its main ingredients so the medicine can enter the bloodstream.
What is polyethoxylated castor oil?
Polyoxyl castor oil (polyethoxylated castor oil, Kolliphor EL, or Cremophor EL) is prepared by reacting ethylene oxide with castor oil in a ratio of 35:1. This results in a compound in which the hydroxyl groups of the castor oil triglyceride are ethoxylated, forming polyethylene glycol ethers .
What is peg 40 made from?
PEG-40 hydrogenated castor oil is an emollient and emulsifying agent created from a mixture of synthetic polyethylene glycol (PEG) + natural castor oil. It also helps other ingredients solubilize in a formula which improves both aesthetics and performance.
Is peg 40 halal?
[INCI Name] PEG-40 HYDROGENATED CASTOR OIL Halal Certified.
What is the difference between castor oil and hydrogenated castor oil?
Hydrogenated Castor Oil, also known as castor wax, is derived from castor beans (Ricinus communis), which is typically a liquid at room temperature, that has been processed by adding hydrogen to make it more stable and raises its melting point so that it is a solid at room temperature.
Is polyoxyl a 40 stearate?
An octadecanoate ester composed of repeating 8-40 ethyleneoxy units. It is an ingredient used in cosmetics and beauty products primarily as a surfactant and emulsifier….CHEBI:32027.
|polyoxyl 40 stearate
|polyoxyl 8 stearate
|stearic acid, monoester with polyethylene glycol
What is the solvent in Taxol?
Taxol uses a solvent called Cremophor EL to dissolve its main ingredients so the medicine can enter the bloodstream. Cremophor EL can make Taxol harder to tolerate. So people usually take medicine before receiving Taxol to minimize any reactions to the solvent. Abraxane doesn’t use a solvent.