What does a positive anti-Jo-1 mean?

What does a positive anti-Jo-1 mean?

Background: It is widely believed that patients bearing auto-antibodies to histidyl tRNA synthetase (anti-Jo-1) very likely have a connective tissue disease including myositis and interstitial lung disease. The value of positive tests in low disease prevalence settings such as those tested in routine care is unknown.

What disease are anti-Jo-1 antibodies most often associated with?

Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis.

What causes Jo 1 antibody?

Anti-Jo1 antibody-positive myositis, associated with pleural effusions, pericardial effusion with tamponade, and “mechanic’s hands,” was attributed to the consumption of Kombucha “mushroom” [47].

What is anti-Jo-1 syndrome?

BACKGROUND Anti-Jo-1 antibodies occur in syndromes that may include muscle weakness and pain, Raynaud’s phenomenon, interstitial lung disease, arthritis, and a skin rash different from that seen in dermatomyositis. The muscle pathology is not well defined.

What are scleroderma antibodies?

Antinucleolar antibodies have been reported in 15% to 40% of patients with scleroderma [15•]. Although these antibodies are considered specific for scleroderma, anti- nucleolar antibodies can occur in other autoimmune dis- eases, such as SLE, PM or dermatomyositis, and RA [17].

What are the symptoms of myositis?


  • Difficulty standing up from a seated position.
  • Difficulty climbing stairs.
  • Difficulty lifting the arms.
  • Fatigue after standing or walking a long time.
  • Trouble swallowing or breathing.
  • Muscle pain that does not subside within a few weeks.
  • A red or purple colored rash on the eyelids, elbows, knees and knuckles.

What is Jo 1 in blood test?

A positive result for Jo 1 antibodies is consistent with the diagnosis of polymyositis and suggests an increased risk of pulmonary involvement with fibrosis in such patients. A negative test for Jo 1 antibodies does not exclude the diagnosis of polymyositis or dermatomyositis.

How did I get polymyositis?

The exact cause of polymyositis is not known. It most often happens in people ages 31 to 60. It rarely occurs in people younger than 18. Experts think that polymyositis may be related to or triggered by a virus or an autoimmune reaction.

What triggers polymyositis?

Experts think that polymyositis may be related to or triggered by a virus or an autoimmune reaction. An autoimmune reaction is when the body attacks its own tissues. In some cases, a medicine may lead to an allergic response that causes muscle irritation and damage.

What antibodies are positive in scleroderma?

Blood Changes Approximately 95% of people with systemic scleroderma have a positive antinuclear antibody (ANA) test, but so do people with other autoimmune diseases (97% of people with lupus, as an example). People with localized scleroderma usually have negative ANA.

  • August 2, 2022