How is cisplatin ototoxic?
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How is cisplatin ototoxic?
In clinical practice, ototoxicity is the major dose-limiting side effect of cisplatin, requiring discontinuation and replacement by another second-line chemotherapeutic agent, usually carboplatin, or accepting the hearing loss, which is sometimes severe.
What is cisplatin induced hearing loss?
But cisplatin and other similar platinum-containing drugs can damage the cochlea, leaving 40%–80% of adults, and at least 50% of children, with significant permanent hearing loss, a condition that can greatly affect quality of life.
Is hearing loss from cisplatin permanent?
People under age 3 and over age 50 are at a higher risk for this type of hearing loss, as are people being treated with the chemotherapy treatment cisplatin (more on that in a moment). This type of hearing loss is permanent.
How can cisplatin ototoxicity be prevented?
To summarize, the most suitable protocol for treating cisplatin-induced ototoxicity is intratympanic injection to be delivered 1h before each cisplatin injection, due to superior perilymph concentrations within 1 h of administration (Chandrasekhar et al., 2000; Hargunani et al., 2006).
How common is hearing loss with cisplatin?
Dose-related ototoxicity is illustrated by the report that 20% of patients treated with cisplatin for testicular cancer experience permanent ototoxicity, but > 50% of patients who received cisplatin in doses > 400 mg/m2 cumulative dose had permanent hearing loss (Bokemeyer et al.
Can cisplatin cause ringing in ears?
Hearing loss affects one in five patients treated with cisplatin and nearly one in five patients with carboplatin, Dr. Schink says. The drugs also are associated with tinnitus, a condition that causes noise or ringing in the ears. Hearing loss or tinnitus caused by the drugs typically doesn’t go away.
Is ototoxicity from cisplatin reversible?
Dose limiting side effects of cisplatin include nephrotoxicity, neurotoxicity and ototoxicity. While nephrotoxicity can to some extent be reversed by increasing saline hydration as well as mannitol diuresis, there are no known cures or preventative treatments available for ototoxicity and neurotoxicity.
