What type of drug is mephobarbital?
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What type of drug is mephobarbital?
Mebaral (mephobarbital) is a barbiturate used as a sedative to treat anxiety, tension, and apprehension (dreading or feeling uneasy about what you think may happen). Mebaral is also used to treat seizures. Mebaral is available in generic form.
What is the classification of phenobarbital?
Phenobarbital is in a class of medications called barbiturates. It works by slowing activity in the brain.
What is the log P of phenobarbital?
It also inhibits glutamate induced depolarizations. [PubChem] Phenobarbital acts on GABAA receptors, increasing synaptic inhibition….Structure for T3D3006: Phenobarbital.
| Property | Value | Source |
|---|---|---|
| Water Solubility | 0.28 g/L | ALOGPS |
| logP | 1.4 | ALOGPS |
| logP | 1.41 | ChemAxon |
| logS | -2.9 | ALOGPS |
When should you not use mephobarbital?
Before taking mephobarbital, tell your doctor if you have liver or kidney disease, anemia, heart disease, asthma or other breathing disorder, or a history of depression, mental illness, suicide attempt, or drug/alcohol addiction. Do not use mephobarbital without telling your doctor if you are pregnant.
Is mephobarbital a medical drug?
Mebaral is a prescription medicine used to treat the symptoms of Anxiety, Tension, Apprehension, and Epilepsy. Mebaral may be used alone or with other medications. Mebaral belongs to a class of drugs called Barbiturates, Barbiturate Anticonvulsants.
When should phenobarbital levels be taken?
Common labs for monitoring phenobarbital Scheduled monitoring of phenobarbital levels has increased its safety and efficacy. We will usually recommend checking a phenobarbital level 4 weeks after reaching a therapeutic dose and then every 4-12 months thereafter.
What type of seizure is phenobarbital used for?
Phenobarbital is useful in controlling focal aware (formally called simple partial), focal impaired awareness (formerly called complex partial), and generalized tonic-clonic seizures in patients of all ages. It has often been considered the first choice to treat certain kinds of seizures in infants.
Do doctors still prescribe phenobarbital?
Many doctors no longer prescribe it unless other seizure medicines have failed, however, because of concern that its side effects often outweigh its benefits (except for certain groups such as very young children).
Is placidyl still prescribed?
Abbott discontinued production in 1999, due to it being replaced by the benzodiazepine family and its widespread abuse, after which Placidyl was available for about a year in the United States.
Is mephobarbital a prodrug?
Mephobarbital is the N-methyl analog of phenobarbital which functions as prodrug of the latter due to N-demethylation in the hepatic endoplasmic recticulum.
How are phenobarbital levels measured?
Phenobarbital is measured in micrograms per milliliter (mcg/mL). The normal therapeutic range for adults is around 15 to 40 mcg/mL. If your blood level is too high, you may need to have your dose lowered. If your blood level is too low, you may need to have your dose increased.
When should phenobarbital levels be checked?
Common labs for monitoring phenobarbital We will usually recommend checking a phenobarbital level 4 weeks after reaching a therapeutic dose and then every 4-12 months thereafter.
When should I take phenobarbital level?
Phenobarbital
- A serum concentration should be obtained 30-60 minutes after IV loading dose.
- Additional levels should be obtained:
- On-going levels can be drawn any time during dosing interval after steady state due to long half-life.
What is the meaning of mephobarbital?
Mephobarbital Description. Mephobarbital, 5-Ethyl-1-methyl-5-phenylbarbituric acid, is a barbiturate with sedative, hypnotic, and anticonvulsant properties. It occurs as a white, nearly odorless, tasteless powder and is slightly soluble in water and in alcohol. Mephobarbital tablets are available for oral administration.
What are the symptoms of overdose of mephobarbital?
Symptoms of overdose of mephobarbital include confusion, decrease in or loss of reflexes, somnolence, fever, irritability, hypothermia, poor judgment, shortness of breath or slow/troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness.
How long does it take for mephobarbital to work?
Therapeutic plasma concentrations for Mephobarbital have not been established nor has the half-life been determined. Following oral administration, the onset of action of the drug is 30 to 60 minutes and the duration of action is 10 to 16 hours.
Does mephobarbital make you feel drowsy?
Mephobarbital tablets usually causes little or no drowsiness or lassitude. Hence, when it is used as a sedative or anticonvulsant, patients usually become more calm, more cheerful, and better adjusted to their surroundings without clouding of mental faculties.
