What is the difference between cisplatin carboplatin and oxaliplatin?
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What is the difference between cisplatin carboplatin and oxaliplatin?
Brief Summary: Cisplatin is a widely used anti-tumor agent for the treatment of testicular and ovarian cancers. Carboplatin is used extensively for small cell, non small cell lung cancer and ovarian cancer. Oxaliplatin has recently been approved in the United States (US) for treatment of colorectal cancer.
Is carboplatin less effective than cisplatin?
There is no definite overall survival difference between cisplatin or carboplatin based first-line chemotherapy. Cisplatin-based chemotherapy is associated with more severe nausea and vomiting and nephrotoxicity; severe thrombocytopaenia is more frequent during carboplatin-based chemotherapy.
What is carboplatin and Alimta?
Carboplatin + Pemetrexed (Alimta®) (Carbo/Pem) is a Chemotherapy Regimen for Lung Cancer, Non-Small Cell Lung Cancer (NSCLC)
Is there another name for carboplatin?
Paraplatin is the trade name for Carboplatin. In some cases, health care professionals may use the trade name Paraplatin when referring to the generic drug name Carboplatin. Drug type: Paraplatin is an anticancer drug (“antineoplastic” or “cytotoxic”) chemotherapy drug.
Why is carboplatin less toxic than cisplatin?
Carboplatin is primarily eliminated through the kidneys. Its elimination is slower than cisplatin with a terminal half-life between 2 and 6 hours. After IV injection, approximately 60% of the total drug is excreted within 24 hours.
What is the most neurotoxic chemo?
Among the platinum compounds in clinical use, cisplatin is the most neurotoxic, inducing mainly sensory neuropathy of the upper and lower extremities.
What is carboplatin pemetrexed?
What is pemetrexed and carboplatin? Pemetrexed and carboplatin is a combination treatment used to treat mesothelioma and non-small cell lung cancer (NSCLC). It is best to read this information with our general information about chemotherapy and the type of cancer you have.
What is pemetrexed plus carboplatin?
Pemetrexed plus carboplatin (PC) had better chemotherapy compliance and efficiency in advanced non-squamous NSCLC patients. The aim of our study was to investigate the feasibility and efficacy of PC as adjuvant chemotherapy in patients with completely resected non-squamous NSCLC.
What does eviQ stand for?
| Identifying and definitional attributes | |
|---|---|
| Metadata item type: | Data Element |
| Definition: | The eviQ protocol identifier for the systemic therapy agent protocol administered during the initial course of treatment for cancer. |
| Data Element Concept: | Cancer treatment—systemic therapy agent or protocol |
What class of chemotherapy is carboplatin?
Carboplatin is an anticancer drug (“antineoplastic” or “cytotoxic”) chemotherapy drug. Carboplatin is classified as an “alkylating agent.”
Is there an alternative to cisplatin?
In the case of absolute interdiction of cisplatin, several alternative regimens incorporating carboplatin, 5-fluorouracil, cetuximab, and docetaxel are available.
Is carboplatin a cardiotoxic?
Other cytostatics more frequently correlated with cardiotoxic side effects are taxanes (paclitaxel, docetaxel), alkylating agents (Carboplatin, Cisplatin, Cyclophosphamide), small molecule tyrosine kinase inhibitors (lapatinib, imatinib, sorafenib, sunitinib) and trastuzumab, a monoclonal antibody directed against the …
Is carboplatin a neurotoxic?
Carboplatin is generally considered to be less neurotoxic than cisplatin, but it is associated with a higher risk of neurological dysfunction if administered at high dose or in combination with agents considered to be neurotoxic. Oxaliplatin induces two types of peripheral neuropathy, acute and chronic.
What kind of chemo is pemetrexed?
Pemetrexed belongs to the class of chemotherapy drugs called antimetabolites. Antimetabolites are very similar to normal substances within the cell. When the cells incorporate substances like pemetrexed into themselves during growth, the cells lose the ability to divide.
What type of drug is pemetrexed?
Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by blocking the action of a certain substance in the body that may help cancer cells multiply.
What is chemotherapy eviQ?
A free resource of evidence-based, consensus driven cancer treatment protocols and information for use at the point of care. eviQ is developed for the Australian context and supports health professionals in the delivery of cancer treatments.
What is eviQ and when should it be used?
eviQ is an Australian Government, freely available online resource of cancer treatment protocols developed by multidisciplinary teams of cancer specialists.
What is the trade name for carboplatin?
Paraplatin is the trade name for Carboplatin. In some cases, health care professionals may use the trade name Paraplatin when referring to the generic drug name Carboplatin.
Is cisplatin a strong chemo drug?
Presently, cisplatin is one of the most powerful chemotherapeutic drugs used for the treatment of ovarian cancer; even though resistance is typical [20]. In ovarian germ cell cancer, the use of cisplatin brings about high response rates [21].
