What is hepatoprotective agent?

What is hepatoprotective agent?

Any compound that is able to prevent damage to the liver.

What is potent hepatoprotective?

WikiProject Medicine may be able to help recruit an expert. ( October 2017) Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver.

What are hepatotoxic agents?

– Drugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves (higher concentrations cause more liver damage) and well characterized mechanisms of toxicity, such as directly damaging liver tissue or blocking a metabolic process.

What is hepatotoxicity PDF?

Hepatotoxicity is the injury or liver damage caused by exposure to drugs; it is an adverse drug reaction that may be uncommon but serious. The hepatic injury can be classified into hepatocellular, cholestatic and mixed, caused by increase in alanine aminotransferase and alkaline phosphatase than upper limit of normal.

Which drug is used in hepatoprotective drug?

Silymarin is a combination of different ingredients with silibinin as the most active among them (Surai, 2015). Silymarin has been approved for clinical studies in treating the Hepatitis C virus infection (Ferenci et al., 2008). There are many studies on the mechanism of hepatoprotective effects of silymarin.

Which Phytoconstituents are hepatoprotective in nature?

These hepatoprotective plants have the phytoconstituents such as phenyl compounds, coumarins, essential oils, monoterpenoids, diterpenoids, triterpenoids, steroids, alkaloids and other nitrogenous compounds.

What does the word hepatotoxic mean?

state of toxic damage to the liver
Definition of hepatotoxicity 1 : a state of toxic damage to the liver. 2 : a tendency or capacity to cause hepatotoxicity.

What causes hepatotoxicity?

Toxic liver disease is damage to your liver. It’s also called hepatotoxicity or toxic hepatitis. It can cause serious symptoms or liver damage if you don’t get help. Medications, herbal supplements, chemicals, solvents, and alcohol are all possible causes of hepatotoxicity.

Which of these Phytoconstitutent is hepatoprotective in nature?

What causes Dili?

Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes.

Is azithromycin hepatotoxic?

Azithromycin hepatotoxicity is typically associated histologically with a cholestatic hepatitis similar to what is described with erythromycin induced liver injury. Scattered bile casts are found in canaliculi with modest parenchymal inflammation and necrosis.

What causes hepatotoxic?

Toxic hepatitis occurs when your liver develops inflammation because of exposure to a toxic substance. Toxic hepatitis may also develop when you take too much of a prescription or over-the-counter medication. The liver normally removes and breaks down most drugs and chemicals from your bloodstream.

How do you prevent hepatotoxicity?

For preventing acquired resistance and a successful treatment; it is recommended to start with a combination chemotherapy containing INH, RMP, and Pyrazinamide (PZA)-one more hepatotoxic agent- with or without ethambutol for the initial 2 mo followed by a continuation phase of 4-6 mo of INH + RMP[5].

How do you treat DILI?

Early diagnosis and withdrawal of the suspected medication is the mainstay of treatment of DILI. For acetaminophen and Amanita mushroom poisoning, there are specific therapies in use. Finally, there are other possible management modalities for DILI, including corticosteroids and ursodeoxycholic acid.

How do you diagnose DILI?

DILI remains a diagnosis of exclusion based primarily on a detailed history and judicious use of blood tests, hepatobiliary imaging, and liver biopsy. Diagnostic algorithms available to the clinician are based on clinical scoring systems (31,32,34).

Which antibiotic is best for jaundice?

Ceftriaxone and Jaundice in Neonates (CEFT) Brief Summary: Ceftriaxone is an antibiotic often used for the management of sepsis. Neonates commonly have jaundice during the first postnatal week. Ceftriaxone will be given as standard of care for sepsis and investigators will observe the effect on jaundice.