What does prothrombin complex concentrate do?

What does prothrombin complex concentrate do?

Prothrombin complex concentrate (PCC), also known as factor IX complex, is a medication made up of blood clotting factors II, IX, and X. Some versions also contain factor VII. It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available.

When is prothrombin complex concentrate indicated?

, Prothrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding.

What is prothrombin complex concentrate made from?

Prothrombin Complex Concentrates Prepared from large pools of normal donor plasma, the PCCs contain the vitamin K–dependent clotting factors prothrombin, FVII, FIX, and FX, as well as anticoagulant proteins C and S.

How long does prothrombin complex take to work?

It usually reverses warfarin anticoagulation within 10-30 minutes.

What is four factor prothrombin complex concentrate?

Four-factor prothrombin complex concentrate (4F-PCC) is the term used to describe a pathogen-reduced, lyophilized concentrate that contains therapeutic amounts of at least 4 coagulation factors: Factor II (FII), Factor VII (FVII), Factor IX (FIX), and Factor X (FX).

What is a benefit of using PCC instead of FFP in this patient?

As regards safety monitoring and adverse drug reaction screening in the FFP group, the INR was high (INR > 2.5) in 86% of the patients. There was no report of hemorrhage in both groups. PCC reverses anticoagulation both effectively and safely while having the advantage of obviating the need to extra doses.

What is four factor Prothrombin complex concentrate?

How long does Prothrombin complex concentrate last?

Data on PCC pharmacokinetics are scant. The half-lives of the four clotting factors differ widely. The half-life of FII is much longer (60–72 h) than that of the other factors (6–24 h). FVII has the shortest half-life (approximately 6 h)4.

How long does prothrombin complex concentrate last?

When do we use 4 factor PCC?

Current guidelines recommend 4-factor PCC for situations where rapid reversal of VKA-induced coagulopathy is needed, such as in patients who require urgent surgery or in those with a life-threatening bleed.

When do you give FFP vs PCC?

FFP is the standard of care in the United States ; however, FFP needs to be given in a dose of 15-20 mL/kg and therefore requires a large-volume infusion. PCC contains high levels of vitamin K-dependent cofactors and thus involves a smaller-volume infusion than FFP and more rapid administration.

How much does prothrombin complex concentrate cost?

Kcentra® is supplied as a 500-unit single dose vial. Kcentra® is dosed according to Factor IX potency and is individualized based on the patient’s baseline International Normalized Ratio (INR) and body weight. The cost of Kcentra® is $1.27 per unit; a single dose of Kcentra® for an 80 kg patient costs $5,080.

Is prothrombin complex concentrate a blood product?

Prothrombin Complex Concentrate (PCC) | Best Blood. Prothrombin Complex Concentrates (PCC) are human plasma derived products that have undergone solvent/detergent treatment and/or nanofiltration for viral, bacterial and parasite inactivation and removal.

Why is PCC preferred over FFP?

Prothrombin complex concentrate offers several advantages over FFP, most importantly, the small volume needed to reverse anticoagulation. PCC contains significantly higher amounts of the clotting factors compared to FFP; one dose of PCC equals 8 to 16 units of FFP.

How do you administer prothrombin complex concentrate?

Diluted prothrombin complex concentrate should be administered by IV infusion at a rate of 0.12 mL/kg/min (about 3 units/kg/min) up to a maximum rate of 8.4 mL/min (about 210 units/min).

  • October 2, 2022