What does DC-SIGN stand for?
Table of Contents
What does DC-SIGN stand for?
Dendritic Cell-Specific Intercellular adhesion molecule
DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene.
What cells express DC-SIGN?
DC-SIGN, which is expressed by dendritic cells, binds to ICAM-3 on T-lymphocytes, therefore playing an important role in the activation of T-lymphocytes. DC-SIGN can also bind HIV, and the virus may remain bound to DC-SIGN for protracted periods.
What is DC SIGN receptor?
Interestingly, DC-SIGN is a cell adhesion receptor as well as a pathogen recognition receptor. As adhesion receptor, DC-SIGN mediates the contact between dendritic cells (DCs) and T lymphocytes, by binding to ICAM-3, and mediates rolling of DCs on endothelium, by interacting with ICAM-2.
Do macrophages have Fc receptors?
Fc receptors are found on a number of cells in the immune system including phagocytes like macrophages and monocytes, granulocytes like neutrophils and eosinophils, and lymphocytes of the innate immune system (natural killer cells) or adaptive immune system (e.g., B cells).
What are CD11c positive cells?
CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia.
Do macrophages express DC sign?
DC-SIGN is a type II transmembrane C-type lectin with a carbohydrate recognition domain, which is expressed in human DCs and macrophages (Geijtenbeek et al., 2000; Soilleux et al., 2002), and is involved in multiple aspects of the immunological response (van Kooyk and Geijtenbeek, 2003).
Do cytotoxic T cells have Fc receptors?
Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity….Fc receptor.
| Immunoglobulin-like receptor | |
|---|---|
| Membranome | 10 |
What is CD11b marker for?
CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection.
Are macrophages CD11b+?
Our results indicate that macrophages, including CD11b+/Gr-1+ macrophages, play a critical role in antigen clearance and inflammation resolution, and VEGF-C, -D, and -A derived from the macrophages, local inflamed tissue, and DLNs contribute to accelerate antigen clearance and inflammation resolution.
Are monocytes CD11c positive?
Monocytes express typical blood monocyte markers, such as CD14, CD11b, CCR2, and CD16, but at extravascular sites they possess higher levels of CD141, CD11c, HLA-DR, and CCR7, indicating a tissue-imprinted phenotypic change that is reminiscent of DCs (111, 114).
What is the difference between macrophages and dendritic cells?
Macrophages refer to a type of white blood cells that surround and kill microorganisms, remove dead cells, and stimulate the activity of other immune system cells. Dendritic cells refer to a special type of immune cells that boost immune responses by showing antigens on its surface to other cells of the immune system.
Where are C-type lectins found?
In mammals, C-type lectins are found as secreted molecules or as transmembrane proteins (Fig. 1), and they have been implicated in a diverse range of physiological functions because of their ability to recognize self (endogenous) and non-self (exogenous) ligands.
