Does precedex suppress respiratory drive?

Does precedex suppress respiratory drive?

Dexmedetomidine provides important postsurgical analgesia and appears to have no clinically important adverse effects on respiration in the surgical patient who requires intensive care.

Is propofol a respiratory depressant?

Respiratory depression is what makes propofol such a dangerous drug of abuse. Therapeutic doses will decrease the respiratory rate and tidal volume, and impair ventilatory response to carbon dioxide.

Does dexmedetomidine cause respiratory depression?

Dexmedetomidine is safe to use in extubated spontaneous breathing intensive care patients and does not cause clinically significant respiratory depression.

Does propofol cause hypotension?

Propofol is likely to induce hypotension by inhibiting the sympathetic nervous system and by impairing baroreflex regulatory mechanisms 5.

Can you breathe on propofol?

(For instance, Tung explains, cyclical patterns of REM and nonREM sleep are not observed during propofol sedation, in rats or humans) Sleep, in general, preserves blood pressure and the ability to breathe and propofol does not.

What is dexmedetomidine used for?

Dexmedetomidine is used as an adjuvant for premedication, especially in patients susceptible to preoperative and perioperative stress because of its sedative, anxiolytic, analgesic, sympatholytic, and stable hemodynamic profile.

What is the reversal agent for dexmedetomidine?

Atipamezole is a non-selective α2 adrenoceptor antagonist. It rapidly reverses sedation/analgesia induced by dexmedetomidine.

What is the most important side effect of propofol?

Incidence less than 1% – Causal Relationship Unknown

Is propofol general anesthesia or sedation?

Propofol is an intravenous anesthetic used for procedural sedation, during monitored anesthesia care, or as an induction agent for general anesthesia. It may be administered as a bolus or an infusion, or some combination of the two.

Can nurses give Precedex?

Registered nurses must complete a moderate sedation inservice and maintain yearly competency. Sedation nurses may then administer midazolam, Fentanyl, Demerol and morphine, under the physician’s direction.

What is the side effects of dexmedetomidine?

The adverse effects of dexmedetomidine include hypotension, hypertension, nausea, bradycardia, atrial fibrillation, and hypoxia (22, 28) (Figure ​4). Overdose may cause first-degree or second-degree atrioventricular block.

Is dexmedetomidine a sedative?

Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration of mechanical ventilation and delirium among patients in the intensive care unit (ICU).

Can you use precedex and propofol together?

Using propofol together with dexmedetomidine may have increased effects on breathing, heart rate, blood pressure, and sedation. You will be monitored closely by your surgical team during anesthesia, and the doses of each medication adjusted accordingly.