When should mesna be given with cyclophosphamide?

When should mesna be given with cyclophosphamide?

The recommended dose of oral mesna is 40% of the cyclophosphamide or ifosfamide dose, given prior to antineoplastic agents and then repeated at 2 hours and 6 hours after the cyclophosphamide/ifosfamide dose.

Why is mesna given with cyclophosphamide?

The chemotherapy drugs ifosfamide and cyclophosphamide can sometimes irritate the lining of the bladder. This can cause bleeding from the bladder and may show up as blood in your urine (pee). This is called haematuria. Mesna helps protect your bladder to prevent irritation and bleeding.

Is mesna compatible with cyclophosphamide?

Mesna is compatible with cyclophosphamide and ifosfamide in the same infusion fluid and may be admixed for continuous infusion. Diluted solutions are chemically and physically stable for 24 hours at room temperature, 77 degrees F (25 degrees C). Mesna multidose vials may be stored and used for up to 8 days.

When do you use mesna?

Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer).

What is mesna chemotherapy?

About: Mesna (Mesnex®) Mesna is not a cancer treatment, but a medication, called a chemoprotectant, used to protect the bladder from a harmful side effect of certain chemotherapy medications (ifosfamide, cyclophosphamide) called hemorrhagic cystitis (bleeding in the bladder).

What is IV mesna used for?

USES: This medication is used to reduce the risk of bleeding in the bladder (hemorrhagic cystitis), which is a very serious side effect of treatment with a cancer chemotherapy drug called ifosfamide. Mesna helps to protect the lining of the bladder against damage from ifosfamide.

What chemo is mesna used with?

Medical uses Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. These two anticancer agents, in vivo, may be converted to urotoxic metabolites, such as acrolein.

How do you use cyclophosphamide mesna?

Where ifosfamide or cyclophosphamide is used as an iv bolus: Mesna is given by intravenous injection over 15-30 minutes at 20% of the simultaneously administered oxazaphosphorine on a weight for weight basis (w/w). The same dose of mesna is repeated after 4 and 8 hours.

How is mesna given?

Mesna is available in 100 mg/ml injection, which can be administered as an injection, as an IV infusion. It is also available as a 400 mg oral tablet.

What type of drug is mesna?

Mesna is classified as a chemoprotective agent. Chemoprotective agents are drugs that are used with certain types of chemotherapy to protect the body from or minimize the side effects of the chemotherapy.

How much does mesna cost?

Mesna is administered by a healthcare professional as a series of injections. Mesna’s cost is normally $30.74 at full price. A SingleCare Mesna coupon reduces that price to $3.55. Ask the clinic or hospital where you receive your Mesna injections if they will accept a SingleCare Mesna coupon; you could pay only $3.55.

What is the mechanism of action of mesna?

Mechanism of action Mesna concentrates in the bladder where acrolein accumulates after administration of chemotherapy and through a Michael addition, forms a conjugate with acrolein and other urotoxic metabolites. This conjugation reaction inactivates the urotoxic compounds to harmless metabolites.

What is mesna chemo?

Can IV mesna be given orally?

mesna doses given at 0, 4, and 8 hours after ifosfamide administration. The investigational regimen included an I.V. mesna dose given concurrently with ifosfamide, followed 2 and 8 hours later by oral administration of mesna tablets. I.V. and oral mesna doses equaled 20% and 40%, respectively, of the ifosfamide dose.

How do you administer mesna?

Mesna is available in 100 mg/ml injection, which can be administered as an injection, as an IV infusion. It is also available as a 400 mg oral tablet. There is no information reported for dose adjustment in patients with hepatic impairment.

How do you give oral mesna?

Oral Mesna should be taken as the combined infusion of ifosfamide and Mesna finishes, then at 2 hours and 6 hours after the time at the finish of the infusion. All oral Mesna doses should be 40% (w/w) of the final 24 hour ifosfamide dose rounded down to the nearest whole tablet.

How do you mix mesna?

Preparation of Intravenous Solutions/Stability One mL of Mesna Injection multidose vial 100 mg/mL may be added to 4 mL of any of the solutions listed above to create a final concentration of 20 mg mesna/mL. Diluted solutions are chemically and physically stable for 24 hours at 25°C (77°F).

Why does cyclophosphamide cause hemorrhagic cystitis?

Cyclophosphamide causes hemorrhagic cystitis by renal excretion of its hepatic metabolite, acrolein, which is urotoxic.

Can mesna be taken orally?

Oral mesna is taken by mouth, usually 2 and 6 hours after you receive ifosfamide. Mesna is given either in a series of 3 injections spaced 4 hours apart, or as a single injection followed by 2 oral doses spaced 2 and 6 hours later. Follow your doctor’s dosing instructions very carefully.

Is mesna a chemo?

Mesna is classified as a chemoprotective agent. Chemoprotective agents are drugs that are used with certain types of chemotherapy to protect the body from or minimize the side effects of the chemotherapy. These medications do not eliminate side effects in general.