What is equipoise in clinical trial?

What is equipoise in clinical trial?

Equipoise is traditionally defined as a state of genuine uncertainty on the relative value of 2 approaches being compared in a trial. 1. After its inception, equipoise became rapidly embraced as a necessary condition for randomization in clinical trials.

Is clinical equipoise necessary?

Clinical equipoise provides the principled basis for medical research involving patients randomly assigned to different treatment arms of a clinical trial,4 and is considered a necessary feature for clinical service practitioners to ethically enroll patients into clinical trials.

What is the difference between theoretical and clinical equipoise?

The primary difference between theoretical equipoise and clinical equipoise is that the former requires the physician–researcher to be in a state of uncertainty during all stages of an RCT, whereas the latter requires uncertainty within the expert clinical community.

What is equipoise principle?

The concept of ‘equipoise’, or the ‘uncertainty principle’, has been represented as a central ethical principle, and holds that a subject may be enrolled in a randomized controlled trial (RCT) only if there is true uncertainty about which of the trial arms is most likely to benefit the patient.

In what way is equipoise an ethical issue in clinical trials?

Equipoise holds that an RCT may be initiated ethically if there is a lack of evidence or conflicting evidence regarding the treatment(s) or intervention(s) in question. As a result, equipoise supports the evaluation of routinely used treatment when evidence of its efficacy is lacking.

How do you use clinical equipoise in a sentence?

The report from the roundtable supported the principle of clinical equipoise and recommended limiting placebo arms to circumstances where clinical equipoise exists. Clinical equipoise is identified as the guiding moral criterion in the Tri-Council Policy Statement: Ethical conduct of Research Involving Humans.

Is the concept of clinical equipoise still relevant to research?

Yes—Spencer Phillips Hey, Alex John London, Charles Weijer Whether they are in their doctor’s clinic or participating in a randomised controlled trial, patients have an interest in receiving competent medical care. Doctors also have a duty to provide patients with care consistent with professional standards.

What is equipoise loss?

According to Merriam-Webster dictionary, the word “Equipoise” means a state of equilibrium. In clinical trial, the concept of ‘clinical equipoise’ means that there is genuine uncertainty over whether a treatment will be beneficial.

What is one solution to the dilemma of clinical equipoise?

What is one solution to the dilemma of clinical equipoise? Compare treatments when there is uncertainty about which treatment is best.

What is equipoise good for?

Equipoise (Boldenone Undecylenate Injection) is recommended as an aid for treating debilitated horses when an improvement in weight, haircoat or general physical condition is desired. Debilitation often follows disease or may occur following overwork and overexertion.

How does the concept of equipoise solve the ethical problem pertaining to clinical trials?

Clinical equipoise helps to resolve the ethical tensions raised by harm-benefit assessments in RCTs by providing a principled justification for the ethical permissibility of a trial.

Is boldenone the same as equipoise?

Boldenone undecylenate, or boldenone undecenoate, sold under the brand names Equipoise and Parenabol among others, is an androgen and anabolic steroid (AAS) medication which is used in veterinary medicine, mainly in horses. It was formerly used in humans as well.

Is Equipoise a testosterone?

The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT)….Boldenone undecylenate.

Clinical data
Trade names	Boldane, Equipoise, Parenabol, Vebonol, others

What kind of steroid is Equipoise?

Equipoise is a steroid ester possessing marked anabolic properties and a minimal amount of androgenic activity. Anabolic and androgenic agents have come to be used widely in the treatment of certain pathophysiological or catabolic processes in man and animals.

Which of the following most accurately describes clinical equipoise group of answer choices?

Which of the following most accurately describes clinical equipoise: Scientific uncertainty that one study intervention is superior to another.

Is Equipoise a DHT?

Which of the following most accurately describes clinical equipoise quizlet?

Which of the following most accurately describes clinical equipoise: Scientific uncertainty that one study intervention is superior to another. Risks to research participants must be completely eliminated for the study to be considered ethical.

What are the three ethical principles from the Belmont Report that constitute the basis for the HHS human subjects regulations 45 CFR 46 )?

The Belmont Report identifies three fundamental ethical principles for all human subjects research — respect for persons, beneficence, and justice.