What is COSMIC used for?
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What is COSMIC used for?
COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world’s largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Start using COSMIC by searching for a gene, cancer type, mutation, etc.
How do I search in COSMIC database?
The COSMIC database. To browse COSMIC you can simply navigate to the main page and search for a gene, cancer type, mutation, etc in the search box. To illustrate we will explore the results for a single gene. Type BRAF in the search interface and hit enter.
What is cancer gene?
The most commonly mutated gene in people with cancer is p53 or TP53. More than 50% of cancers involve a missing or damaged p53 gene. Most p53 gene mutations are acquired. Germline p53 mutations are rare, but patients who carry them are at a higher risk of developing many different types of cancer.
How many genes are involved in cancer?
So far, 291 cancer genes have been reported, more than 1% of all the genes in the human genome. 90% of cancer genes show somatic mutations in cancer, 20% show germline mutations and 10% show both.
What is cosmic matter?
n fine particles of solid matter occurring throughout interstellar space and often collecting into clouds of extremely low density.
How do you reference cosmic?
How should I cite COSMIC? We are very happy for you to use the data, and any tabulations or graphic screenshots which support your work. Please cite the website address (cancer.sanger.ac.uk) and the paper COSMIC: the Catalogue of Somatic Mutations in Cancer Thank you.
What type of mutation is missense?
Listen to pronunciation. (MIS-sens myoo-TAY-shun) A genetic alteration in which a single base pair substitution alters the genetic code in a way that produces an amino acid that is different from the usual amino acid at that position.
Are you born with cancer?
The gene mutations you’re born with and those that you acquire throughout your life work together to cause cancer. For instance, if you’ve inherited a genetic mutation that predisposes you to cancer, that doesn’t mean you’re certain to get cancer. Instead, you may need one or more other gene mutations to cause cancer.
What is the meaning of cosmic space?
In mathematics, particularly topology, a cosmic space is any topological space that is a continuous image of some separable metric space.
