What is Bisalbuminemia?
Table of Contents
What is Bisalbuminemia?
Bisalbuminemia or alloalbuminemia is an inherited or acquired, rarely encountered serum protein anomaly, characterized by the occurrence of bicuspid electrophoretic pattern in the albumin fraction detected on serum electrophoresis. It can be seen in densitometry as a bifid mountain where albumin has two heads.
What is the principle of protein electrophoresis?
Principle The separation of proteins by electrophoresis is based on the fact that charged molecules usually migrate through a matrix/medium upon application of an electrical field [3].
What is M band in serum protein electrophoresis?
Serum protein electrophoresis is most commonly ordered when multiple myeloma is suspected and observation of a monoclonal band (M band, paraprotein) indicates that monoclonal gammopathy may be present in the patient.
What is hereditary Bisalbuminemia?
Hereditary bisalbuminemia is a relatively rare genetic disorder, usually revealed by chance. The causative genetic lesion is a point mutation of human serum albumin gene, inherited in an autosomal codominant pattern3. Almost 70 discrete polymorphisms have been described worldwide.
What causes Hyperalbuminemia?
Serum albumin levels increase in parallel with increased protein intake [1,2] and dehydration is the only known cause of hyperalbuminemia in humans. Our recent findings in two patients suggest that a high-protein diet may be associated with transient elevations in transaminases leading to hyperalbuminemia in humans.
Why did my doctor order serum protein electrophoresis?
Your doctor will usually order a UPEP test if they suspect that you have a condition that causes elevated protein levels in urine, such as multiple myeloma or amyloidosis. Your doctor may also order this test if an earlier test showed there was protein in your urine.
What is a normal M protein level?
Normal range: 6.3-7.9 g/dL The total level of protein in the blood is measured by a total serum protein test.
How can I lower my urine microalbumin naturally?
How can albuminuria be reduced?
- lose weight, if you are overweight.
- avoid foods high in sodium or salt.
- eat the right amounts and types of protein.
What is normal electrophoresis?
Normal Results Normal value ranges are: Total protein: 6.4 to 8.3 grams per deciliter (g/dL) or 64 to 83 grams per liter (g/L) Albumin: 3.5 to 5.0 g/dL or 35 to 50 g/L. Alpha-1 globulin: 0.1 to 0.3 g/dL or 1 to 3 g/L. Alpha-2 globulin: 0.6 to 1.0 g/dL or 6 to 10 g/L.
What causes high protein levels in blood?
Certain proteins in the blood may be elevated as your body fights an infection or some other inflammation. People with certain bone marrow diseases, such as multiple myeloma, may have high blood protein levels before they show any other symptoms.
