Can ondansetron cause dystonia?

Can ondansetron cause dystonia?

Conclusions: Dystonia and seizures have been associated with ondansetron in a few case reports. In addition, clinicians need to consider hypoglycemia as a possible adverse effect of ondansetron.

What drug treats acute dystonia?

The most commonly available drugs in the emergency setting for the treatment of acute dystonic reactions are diphenhydramine and benztropine. Symptoms usually improve or resolve dramatically within 10 to 30 minutes of administration of parenteral anticholinergics.

Is ondansetron associated with extrapyramidal symptoms?

Abstract. Ondansetron can rarely induce extrapyramidal reactions in susceptible individuals. Our patient had a history of drug-induced dystonic reaction; therefore, these patients may be susceptible to extrapyramidal adverse reactions after ondansetron.

What medications make dystonia worse?

High potency antipsychotic drugs such as haloperidol, fluphenazine, and pimozide cause dystonia more frequently than do low potency drugs such as chlorpromazine and thioridazine.

What does ondansetron treat?

Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Why does metoclopramide cause extrapyramidal symptoms?

Although the possible reason of extrapyramidal side effects presentation is a blockage of striatal D2 receptor, their exact mechanism remains unclear [9]. The most often types of extrapyramidal side effects due to Metoclopramide usage are parkinsonism, tardive dyskinesia, acute dystonias and akathisia.

How is Oculogyric crisis treated?

Treatment. Severe or painful oculogyric crises can be treated acutely with benztropine or diphenhydramine, intramuscularly or intravenously. A dose can be repeated in 30 minutes if there is no response. If these are unsuccessful, then diazepam or lorazepam, intramuscularly or intravenously, can be used.

How do anticholinergics treat dystonia?

The effect of anticholinergic drugs is believed to be mediated through the blockage of muscarinic acetylcholine receptors, thus restoring the imbalance between striatal dopamine and acetylcholine, both involved in the pathophysiology of dystonia (Pisani et al.

What is the mechanism of action of ondansetron?

Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Which antiemetics are known to cause extrapyramidal symptoms?

Although extrapyramidal side effects of two commonly used antiemetics, metoclopramide and prochlorperazine, are well known, it may be difficult for even the experienced practitioner to distinguish some of these extrapyramidal reactions from such psychiatric symptoms as anxiety, depression, or catatonia.

Is Oculogyric crisis reversible?

The management is the same as for dystonias caused by antipsychotics, that is, anticholinergics and reassurance. Our case report highlights the fact that oculogyric crises caused by drugs may be reversible and prognosis may be good.

Is there a difference between Zofran and ondansetron?

Zofran (ondansetron) is a medication used to prevent nausea and vomiting caused by cancer medications (chemotherapy), radiation therapy, and surgery. Zofran (ondansetron) works by blocking the actions of serotonin, a natural substance in your body, that may cause nausea and vomiting.

What medications can cause oculogyric crisis?

Drugs that can trigger an oculogyric crisis include neuroleptics (such as haloperidol, chlorpromazine, fluphenazine, olanzapine), carbamazepine, chloroquine, cisplatin, diazoxide, levodopa, lithium, metoclopramide, lurasidone, domperidone, nifedipine, pemoline, phencyclidine (“PCP”), reserpine, and cetirizine, an …

How is drug induced dystonia treated?

Treatment for acute dystonia includes discontinuing the offending drug and treatment with anticholinergics or antihistamines (i.e. diphenhydramine), often injected or intravenously. Even without medical treatment, most cases resolve within 12 to 48 hours.

What is the contraindications of ondansetron?

Contraindications. Ondansetron is contraindicated in patients: known to have hypersensitivity (e.g., anaphylaxis) to Ondansetron or any of the components of the formulation [see Adverse Reactions (6.2)] receiving concomitant apomorphine due to the risk of profound hypotension and loss of consciousness.

Which is better ondansetron or prochlorperazine?

These results demonstrate that prochlorperazine and ondansetron appear to be equally effective at controlling vomiting in patients presenting to the ED with nausea and/or vomiting. Theoretically prochlorperazine may have an advantage over ondansetron, as serotonin can cause the release of dopamine.

Can you take ondansetron with metoclopramide?

In conclusion, a prophylactic combination of ondansetron 4mg with metoclopramide 10mg was clinically effective and well tolerated for the prevention of postoperative nausea and vomiting after total abdominal hysterectomy under general anaesthesia.

What medicines cause oculogyric crisis?

How are dystonic reactions managed in oculogyric crises?

The management of acute dystonic reactions. Although there are case reports of oculogyric crises from other classes of drugs, including H 2 antagonists, erythromycin and antihistamines, the majority of patients will have received an antiemetic or an antipsychotic drug.

Do propofol and ondansetron cause acute dystonic reactions during anesthesia?

Propofol and ondansetron, alone and in combination, have been associated with acute dystonic reactions during recovery from anesthesia. We report the case of a 44-year-old woman who had undergone microlaryngoscopic fat injection to the vocal folds three times over a period of 10 months.

What is the treatment for acute dystonic reactions?

Acute dystonic reactions are a common and distressing complication of antiemetic and antipsychotic drugs. Treatment with intravenous benztropine is safe and produces rapid relief.

Are drug-induced dystonic reactions classified as medical emergencies?

Drug-induced dystonic reactions are common presentations to the emergency department. Two cases of acute dystonic reactions presenting as acute medical emergency illustrate the associated fatality and possibility of misdiagnosis.