What is Involucrin?

What is Involucrin?

Involucrin is a protein component of human skin and in humans is encoded by the IVL gene. In binding the protein loricrin, involucrin contributes to the formation of a cell envelope that protects corneocytes in the skin.

Which sub layer of the epidermis contains keratohyalin?

Stratum granulosum
Stratum granulosum, 3-5 cell layers, contains diamond shaped cells with keratohyalin granules and lamellar granules. Keratohyalin granules contain keratin precursors that eventually aggregate, crosslink, and form bundles.

What secretes lamellar bodies?

In the upper stratum spinosum and stratum granulosum layers of the epidermis, lamellar bodies are secreted from keratinocytes, resulting in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.

What are Germinative cells?

Germinative cells, small cell masses attached to the stalks of dermal papillae that are able to differentiate into the hair shaft and inner root sheath, form follicular bulb-like structures when co-cultured with dermal papilla cells.

What is Germinative layer?

Medical Definition of germinative layer : the innermost layer of the epidermis from which new tissue is constantly formed.

What is in keratohyalin granules?

Keratohyalin granules (KHG) mainly consist of keratin, profilaggrin, loricrin and trichohyalin proteins which contribute to cornification or keratinization, the process of the formation of epidermal cornified cell envelope.

What is the purpose of lamellar bodies?

Lamellar bodies are subcellular structures that have been detected by electron microscopy in various cell types under normal and pathological conditions. The best known and most intensively investigated lamellar bodies are produced by pneumocyte I1 cells in the lung alveoli to provide the lung surfactant system.

What is the function of lamellar granules?

These granules have a role in keratinization and maintaining the barrier functions of the skin. The lamellar granules contain several types of lipids (ceramides, cholesterol, fatty acids) and hydrolytic enzymes including proteases, acid phosphatases, lipases and glycosidases (Downing, 1992; Monteiro-Riviere, 2006).

What are lamellar granules epidermis?

Lamellar granules (LG), also known as keratinosomes, lamellar bodies, membrane-coating granules, and Odland bodies, are specialized secretory granules of the keratinizing stratified squamous epithelia and are thought to be essential in barrier formation and desquamation (Hayward, 1979;Odland and Holbrook, 1981).