What is atracurium used for?
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What is atracurium used for?
Atracurium is indicated as an addition to general anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation. Atracurium is a non-depolarizing neuromuscular blocking drug of the benzylisoquinolinium class.
What are atracurium side effects?
Common side effects of atracurium besylate injection include:
- skin flushing or redness.
- injection site reactions.
- hives.
- itching.
- wheezing.
- shortness of breath.
- allergic reactions.
- inadequate musculoskeletal block.
Is atracurium a sedative?
Risk of apnea. valerian and atracurium both increase sedation. Avoid or Use Alternate Drug.
How is atracurium given?
Atracurium Besilate Injection should only be administered by intravenous injection. Do not give Atracurium Besilate Injection intramuscularly since this may result in tissue irritation and there are no clinical data to support this route of administration.
Is atracurium long acting?
Atracurium has a duration of action, which is shorter than pancuronium and recovery is more rapid than with pancuronium; it is used as an adjunct to general anesthesia for muscle relaxation, for neuromuscular blockade in mechanically ventilated patients in intensive care, and for endotracheal intubation.
What is the antidote for atracurium?
Once evidence of spontaneous recovery is present, the neuromuscular block produced by atracurium besilate can be rapidly reversed by standard doses of anticholinesterase agents, such as neostigmine and edrophonium, accompanied or preceded by atropine or glycopyrrolate, with no evidence of recurarisation.
Can atracurium be given IM?
Use as an adjunct to general anaesthesia Atracurium Besilate Injection should only be administered by intravenous injection. Do not give Atracurium Besilate Injection intramuscularly since this may result in tissue irritation and there are no clinical data to support this route of administration.
Does atracurium lower heart rate?
Endotracheal intubation caused an increase in arterial pressure in all subjects. It is concluded that atracurium has minimal effects on heart rate and arterial pressure when compared with tubocurarine. It does not appear to have a vagal blocking action.
How do you administer atracurium?
Can paralytics be given IM?
Study Objectives: Intravenous administration is the standard route of delivery for paralytic agents used in rapid sequence intubation. However, for emergency department patients with challenging vascular access, intramuscular (IM) delivery may be desired or necessary.
Can atracurium cause tachycardia?
Atracurium, metocurine and in particular d-tubocurarine have histamine-releasing properties and may cause flushing, hypotension and tachycardia.
Does vecuronium drop blood pressure?
Atracurium produced no significant changes in arterial pressure, vecuronium produced a significant fall (20 mmHg) in diastolic pressure during halothane anaesthesia and pancuronium a significant increase in mean arterial pressure with both anaesthetic techniques.
What is the antidote of atracurium?
Can succinylcholine be given IM?
IM succinylcholine was also more reliable at providing clinically adequate intubation conditions at three to four minutes at these doses. With a sufficiently quick onset, IM administration of 4 mg/kg succinylcholine may be an alternative for patients with difficult vascular access requiring intubation.
Can atracurium cause hypertension?
Does atracurium increase heart rate?
It is concluded that atracurium has minimal effects on heart rate and arterial pressure when compared with tubocurarine. It does not appear to have a vagal blocking action.
Can vecuronium increase heart rate?
Vecuronium, rocuronium, and mivacurium also increased heart rate in a dose-dependent manner, but the changes were not statistically significant.
Can rocuronium be given IM?
Rocuronium’s rapid onset and intermediate duration of action with intravenous administration suggests that intramuscular administration might facilitate tracheal intubation without producing prolonged paralysis.
