How do you synthesis aspirin in a lab?
How do you synthesis aspirin in a lab?
SYNTHESIS OF ASPIRIN (acetylsalicylic acid) Place 2.0 g (0.015 mole) of salicylic acid in a 125-mL Erlenmeyer flask. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. H2SO4 (use a dropper, H2SO4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves.
What is the purpose of synthesis of aspirin lab?
The purpose of this lab was to synthesize Aspirin and measure the synthesized Aspirin’s purity. By calculating the theoretical yield based on the original amount of Salicylic acid, one could determine the actual yield percentage of the reaction.
Why is water added in aspirin synthesis?
After the reaction takes place, water is added to destroy the excess acetic anhydride and cause the product to crystallize. The aspirin is then collected, purified by recrystallization, and its melting temperature measured.
What is the reaction equation for the synthesis of acetylsalicylic acid?
*The chemical equation corresponding to the synthesis reaction is: C7H6O3 + (CH3CO)2O → C9H804 + CH3COOH.
How is aspirin purified in a lab?
In this purification method, the crude aspirin will be dissolved in a small amount of warm ethanol. Water will then be added and the solution will be cooled slowly and then chilled. The acetylsalicylic acid will recrystallize, and the solid impurities (unreacted salicylic acid) should remain dissolved in the solution.
Why is sulfuric acid used in aspirin synthesis?
The purpose of adding sulphuric acid (catalyst) is to aid and augent the process of detaching the acetate ion (CH3COO–) from acetic anhydride which ultimately gets associated with H+ ion from phenolic hydroxy group in salicylic acid to be eliminated as a mole of acetic acid. Aim: To prepare aspirin from salicylic acid.
Why is cold water used in aspirin synthesis?
The ice has another role to play. Aspirin is only slightly soluble in water so if you add it to the reaction mixture the product would rather clump together than be in the water phase. This causes the solid to begin to form or ‘precipitate’.
How is aspirin synthesized industrially?
The production process involves the reaction of Salicylic acid and acetic anhydride in glass lined vessels. The liquid produced is pumped to a crystallizer, where it is cooled down to start the crystallization to Aspirin.
Why is phosphoric acid used in aspirin synthesis?
Phosphoric acid acts as a catalyst to accelerate the reaction. (Catalyst is a substance that can be added to a reaction and helps speed up the reaction without getting caught in the process.
What is the limiting reagent in aspirin synthesis?
The salicyclic acid will be the limiting reagent. As far as the calculation of the theoretical yield is concerned, we assume that every mole of salicylic acid will be converted to aspirin or acetylsalicylic acid.
Which Colour is produced in identification test of aspirin?
3. IDENTIFICATION A. Colour Test: Heat the sample with water for several minutes, cool, and add 1 or 2 drops of ferric chloride TS: a violet-red color is produced.
What is the purpose of sulfuric acid in aspirin synthesis?
How can you increase the yield of aspirin synthesis?
Let the flask cool for a few minutes in air, during which time crystals of aspirin should begin to form. Put the flask in an ice bath to hasten crystallization and increase the yield of product. If crystals are slow to appear, it may be helpful to scratch the inside of the flask with a glass rod.
Why is sulphuric acid used in aspirin synthesis?
Making aspirin This reaction would be very slow without a catalyst. In this case just a few drops of sulphuric acid added to the mixture means that there are some free positive hydrogen ions in the solution which can bind to the ethanoic anhydride. This makes it more active and speeds up the reaction.
How is aspirin manufactured and tested on an industrial scale?
The manufacturing of aspirin is done via the use of a reactor, acetic acid, salicylic acid and the use of an acetic anhydride to complete the reaction….Industrial Manufacture and Testing of an Organic Solid.
|Aspirin||Range of melting points (degrees Celsius)|
|Previous year’s practical aspirin||120-151|
How is aspirin tested in industry?
Because today’s aspirin is mass produced in tablet form, Spectrophotometers are a reliable and economical way to keep the purity of Aspirin consistent throughout the manufacturing process. The purity and amount of acetylsalicylic acid in aspirin can be measured using a Visual Spectrophotometer.
What is the purpose of sulphuric acid in aspirin synthesis?
What is the theoretical yield of aspirin in the synthesis experiment?
The calculated theoretical yield was 2.520 grams. Thus, the percent error was 13.93 % and the percent yield was 86.07%. It is important to consider that acetylsalicylic acid is not the only product that forms, acetic acid is another byproduct of the reaction.